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morph Flashcards

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1
Q

Toxic granulations: coarse, dark, abnormal azurophilic (primary) neutrophilic granules

A

sepsis/severe inflamm –> leukocytosis

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2
Q

Dohle bodies: patches of dilated ER seen as sky-blue cytoplasmic puddles

A

sepsis/severe inflamm –> leukocytosis

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3
Q

LNs:

  • Large germinal centers with numerous mitotic figures.
  • Nodes are swollen, gray-red and engorged
  • Endothelial cell hyperplasia (lining the sinus).
A

Acute Nonspecific Lymphadenitis

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4
Q

centeroblasts

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia (dark)

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5
Q

cernteocytes

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia (light)

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6
Q

Tingible-body MF

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia

o Contain the nuclear debris of B cells

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7
Q

immunobalsts

A

Chronic Nonspecific Lymphadenitis: paracortical hyperplasia

-Activated T cells 3-4 times the size of resting lymphocytes

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8
Q

marrow hypercelular w lymphobalsts

A

ALL (acute lymphoblastic leukemia)

-condensed chromatin, less prominent nucleoli, cyto w/o granules

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9
Q

LN archetectural effacement

A
  • C/SLL (chronics,small lymphocytic leukemia)

- follicular lymphoma

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10
Q

LN Proliferation centers Larger lymphocytes gathered in loose aggregates that contain mitotically active cells*

A

C/SLL (chronics,small lymphocytic leukemia)

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11
Q

Smudge cells

A

C/SLL (chronics,small lymphocytic leukemia)

-Small round lymphocytes in the peripheral blood with scant cytoplasm, disrupted when making the smear.

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12
Q

high mititc index; apop; starry sky pattern d/t phagocytosis of nuclear remnants by mf

A

Burkitt lymphoma

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13
Q

centrocytes

A

follicular lymphoma

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14
Q

centroblasts

A

follicular lymphoma

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15
Q

paratrabecular lymphoid aggregates

A

follicular lymphoma

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16
Q

Rouleaux formation

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: increased M protein causes RBCs to stick together linearly in blood smears, indicative, but not specific.
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17
Q

Flame cells

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: intracellular accumulation of degraded protein with fiery red cytoplasm
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18
Q

Mott cells

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: multiple grapelike cytoplasmic droplets
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19
Q

Russel inclusions

A

-multiple myeloma (plasma cell myeloma)
-lymphoplasmacytic lymphoma
= plasma cell: PAS+ cytoplasmic globules

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20
Q

Dutcher inclusinos

A

-multiple myeloma (plasma cell myeloma)
-lymphoplasmacytic lymphoma:
=plasma cell: PAS+ nuclear globules

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21
Q

Heavily infiltrated splenic red pulp = obliteration of white pulp w a beefy red gross appearance.

A

hairy cell leukemia

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22
Q

effaced LNs; mix of variably sized malig T-cells w eos and mfs and neoangiogenesis

A

Peripheral T-cell Lymphoma, Unspecified

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23
Q
  • hallmark cells: anaplastic cells with horseshoe nuclei and voluminous cytoplasm
  • tumor cells surround venules, infiltrating lymphoid sinuses
A

Anaplastic Large Cell Lymphoma

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24
Q

multi-lobated nuclei (‘cloverleaf’ or ‘flower’ cells)

A

Adult T-cell Leukemia/Lymphoma

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25
Epidermis and upper dermis are infiltrated by neoplastic T cells with a cerebriform appearance.
Mycosis Fungoides
26
gneneralized exfoliative erythroderma
Sezary Syndrome
27
leukemia of cells with characteristic cerebriform nuclei
Sezary Syndrome
28
Large lymphocytes with abundant blue cytoplasm and azurophilic granules.
Large Granular Lymphocytic Leukemia
29
destructive nasopharyngeal mass
Extranodal NK/T-cell Lymphoma
30
invades small vessels --> ischemic necrosis
Extranodal NK/T-cell Lymphoma
31
Large azurophilic granules in tumor cell cytoplasm.
Extranodal NK/T-cell Lymphoma
32
Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli AND single round or oblong nucleus with large inclusion like-nucleolus
mononuclear variant of RS cell
33
Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli AND delicate, folded or multilobate nuclei and Abundant pale cytoplasm that retracts during tissue processing = nucleus in an empty hole
lacunar variant of RS cell
34
cell shrinking and becomoing pynknotic
dying (mummicifation) of RS cell
35
Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli AND multilobed nucei: "popcorm cells"
lymphohistiocytic variant of RS cell
36
lacunar variant RS cells
Hodgkin Lymphoma: Nodular Sclerosis Subtype
37
- collagen bands that divide LNs into circumscribed nodules. | - Often involves cervical, supraclavicular and mediastinal LNs
Hodgkin Lymphoma: Nodular Sclerosis Subtype
38
mononuclear variant RS cells
Hodgkin Lymphoma: Mixed cellularity Subtype
39
lymphohistiocytic variant of RS cell
- Hodgkin Lymphoma: Lymphocyte Depletion Subtype | - Hodgkin Lymphoma: Lymphocyte Predominance Subtype
40
aeur rods
- AML, NOS M2, M3 | - AML w genetic abrrs
41
Ring sideroblasts
``` Myelodysplastic syndromes (MDS) (erythroid effect) =Erythroblasts with iron laden mitochondria visible as perinuclear granules ```
42
Neutrophils with Decreased secondary granules, toxic granulations or Dohle bodies
Myelodysplastic syndromes (MDS) (Granulocyte Lineage Effects)
43
Pseudo-pelger-huet cells
``` Myelodysplastic syndromes (MDS) (Granulocyte Lineage Effects) =Neutrophils with only 2 nuclear lobes ```
44
Cells with single nuclear lobes or multiple separate nuclei ('pawn ball')
Myelodysplastic syndromes (MDS) (Megakaryocytic Lineage Effects)
45
hypercellular marrow: basophilia, eosinophila
Chronic Myelogenous Leukemia (CML)
46
hypercellular marrow w residual fat
Polycythemia Vera (PCV or PV)
47
obliterate fibrosis of marrow
spent phase of Polycythemia Vera (PCV or PV)
48
cloudlike clusters of megakaryocytes
late Primary Myelofibrosis (PM)
49
osteosclerosis
late Primary Myelofibrosis (PM)
50
Dacryocytes
``` Primary Myelofibrosis (PM) -Tear drop shaped cells damaged during release from the fibrotic marrow. ```
51
o Abundant, vacuolated cytoplasm o Vesicular nuclei with linear grooves or folds o *Birbeck granules:
Langerhans Cell Histiocytosis | =pantalaminar tubules w dilated terminal end ('tennis racket' appearance) *contain langerin.
52
proliferation of Langerhans cells in medullary cavity of bone typically in the calvarium, ribs, femur.
Unifocal Unisystem Langerhans Cell Histiocytosis (eosinophilic granuloma)
53
nodules and cysts in middle/upper lobes
Pulmonary Langerhans Cell Histiocytosis
54
o Enlarged and soft spleen. o Acute congestion of the red pulp => encroach on and efface lymphoid follicles. o Infiltrates of nfs, plasma cells, +/- eos
Nonspecific Acute Splenitis
55
``` spleen: o Cut surface is gray-red to deep red. o Firm. o Thick, fibrous capsule. o Red pulp: congested then fibrotic. o Becomes fibrous and cellular if long-standing and mineral/pigment deposition too ```
congestive splenomegaly
56
spleen:Bland: pale, wedge shaped, subcapsular, fibrous capsule
splenic infarct
57
spleen: suppurative necrosis that leads to depressed scars.
splenic infarct: septic
58
Hassall corpuscles (whorled) with keratinized cores. (squamous cells)
thymic epithelial cells
59
B germinal centers in thymus
thymic (follicular) hyperplasia
60
thymic cells: : elongated/spindle shaped; swirling, bland oval nuclei w inconspicuous nucleoli
medullary type epithelial cells: noninvasive thymoma
61
thymic cells: Cells are usually cortical with abundant cytoplasm and round, vesicular nuclei. o Numerous reactive lympohoid cells o Capsular invasive
cortical type cells: Invasive (malignant) Thymoma: (but cytologically benign)

heme/lymph (18 decks)

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