Connective Tissue Flashcards

1
Q

Maintain the form of organs throughout the body

A

Connective tissue

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2
Q

Provide a matrix that supports and physically connects other tissues and cells together in organs

A

Connective tissue

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3
Q

__________ of connective tissue gives metabolic support to cells as the medium for diffusion of nutrients and waste products

A

Interstitial fluid

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4
Q

Connective tissue Originate from embryonic

A

mesenchyme

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5
Q

Major constituent of connective tissue is the

A

extracellular matrix (ECM)

Fibers
Ground substances

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6
Q
  • complex of anionic, hydrophilic proteoglycans, glycosaminoglycans (GAGs), and multi-adhesive glycoproteins (laminin, fibronectin, and others)
A

Ground substance

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7
Q

(such as collagens and elastic fibers)

A

Protein fibers

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8
Q

consists of closely aggregated cells connected firmly to one another in the form of cellular sheets that line the interior of hollow organs and cover the body surface

A

EPITHELIAL TISSUE

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9
Q

composed of epithelial cells and a small amount of extracellular matrix

A

EPITHELIAL TISSUE

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10
Q

arranged cellular sheets either in single or multiple layers

A

EPITHELIAL TISSUE

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11
Q

avascular except stria vascularis of the inner ear

A

EPITHELIAL TISSUE

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12
Q

forms the covering of various organs and thus is the outermost tissue in most organs

A

EPITHELIAL TISSUE

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13
Q

various organs like skin, buccal cavity, the lining of blood vessels, body cavities, glands, and their
ducts

A

EPITHELIAL TISSUE

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14
Q

less abundant than connective tissue

A

EPITHELIAL TISSUE

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15
Q

made up of cells, fibers, and gel-like substances that supports and gives structure to the body

A

CONNECTIVE TISSUE

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16
Q

composed of different cells and a
larger amount of extracellular matrix

A

CONNECTIVE TISSUE

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17
Q

scattered throughout the matrix in no particular arrangement

A

CONNECTIVE TISSUE

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18
Q

vascular except for cartilages
poorly vascular-tendons and ligaments

A

CONNECTIVE TISSUE

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19
Q

usually present underneath the epithelial tissue

A

CONNECTIVE TISSUE

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20
Q

forms the bones, cartilages, adipose tissue, reticular tissue, and the blood

A

CONNECTIVE TISSUE

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21
Q

most abundant animal tissue

A

CONNECTIVE TISSUE

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22
Q

Elastic fiber
Collagen fiber
Reticular fiber

A

Protein fibers

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23
Q

Resident cells

A

Mesenchymal cell
Macrophage
Adipocyte
Fibroblast

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24
Q

Product of fibroblasts

A

Extracellular fibers and ground substance

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25
Q

Product of Plasma cells

A

Antibodies

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26
Q

Responsible for Various immune/defense functions

A

Lymphocytes (several types)

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27
Q

Responsible for: Modulate allergic/vasoactive reactions and defense against parasites

A

Eosinophilic leukocytes

ANTIPARASITIC!!!!!!

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28
Q

Responsible for Phagocytosis of bacteria

A

Neutrophilic leukocytes

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29
Q

Responsible for Phagocytosis of ECM components and debris; antigen processing and presentation to immune cells; secretion of growth factors, cytokines, and other agents

A

Macrophages

30
Q

Responsible for: Pharmacologically active molecules (eg, histamine)

A

Mast cells or Basophils

31
Q

Storage of neutral fats

A

Adipocytes

32
Q

Produce and maintain most of the tissue’s extracellular components

A

Fibroblasts

33
Q

Synthesize and secrete collagen and elastin, as well as the GAGs, proteoglycans, and glycoproteins

A

Fibroblasts

34
Q

______ fibroblast - nucleus is large, ovoid, euchromatic, and has a prominent nucleolus

A

Active

35
Q

usually spindle-shaped and contains a darker, more heterochromatic nucleus

A

Quiescent fibroblast “fibrocyte

36
Q

Produce and maintain most of the tissue’s extracellular components
Large, mesenchymally derived cells

A

ADIPOCYTES

37
Q

Specialized for cytoplasmic storage of lipid as neutral fats, or less commonly for the production of heat.

A

Adipocytes

38
Q

Cushion and insulate the skin and other organs

A

Adipocytes

39
Q
  • phagocytic ability and specialize in turnover of protein fibers and removal of dead cells, tissue debris, or other particulate material
A

Macrophages

40
Q

Measures between 10 and 30 μm in diameter and has an eccentrically located, oval or kidney-shaped nucleus.

A

MACROPHAGES

41
Q

MACROPHAGES also known as

A

HISTIOCYTES

42
Q

Macrophages derive from bone marrow precursor cells that divide, producing______

A

monocytes

43
Q

T or F| Monocytes and macrophages are the same cell at different stages of maturation

A

TRUEEEEEEE

44
Q

Oval or irregularly shaped connective tissue cells, between 7 and 20 μm in diameter

A

MAST CELLS

45
Q

Cytoplasm is filled with basophilic secretory granules

Nucleus is centrally situated

Abundant secretory granules

A

Mast cells

46
Q

Roles in the local inflammatory response, innate immunity, and tissue repair.

A

Mast cells

47
Q
  • sulfated GAG that acts locally as an anticoagulant
A

Heparin

48
Q
  • promotes increased vascular permeability and smooth muscle contraction
A

Histamine

49
Q
  • activate various mediators of inflammation
A

Serine proteases

50
Q

attracts leukocytes

A

Eosinophil and neutrophil chemotactic factors

51
Q
  • polypeptides directing activities of leukocytes and other cells of the immune system
A

Cytokines

52
Q
  • precursors for conversion to prostaglandins, leukotrienes, and other important lipid mediators of the
    inflammatory response.
A

Phospholipid

53
Q

B-lymphocyte–derived, antibody- producing cells

Large, ovoid cells have basophilic cytoplasm due to their richness in RER

A

PLASMA CELLS

54
Q

Nucleus is generally spherical but eccentrically placed

Clock-face appearance

A

PLASMA CELLS

55
Q

Wandering cells in connective tissue Leave blood via diapedesis
Increases greatly during inflammation

A

LEUKOCYTES

56
Q

Most abundant protein in the human body

Strong and resistant to normal shearing and tearing forces

A

COLLAGEN

57
Q

Initiated by specific enzymes called collagenases, which are members of an enzyme class called matrix metalloproteinases (MMPs).

A

COLLAGEN DEGRADATION

58
Q

Consist mainly of collagen type III

A

RETICULAR FIBERS

59
Q

Characteristically stained black by impregnation with silver salts - termed argyrophilic

A

RETICULAR FIBERS

60
Q

Occur in the reticular lamina of basement membranes and surround adipocytes, smooth muscle and nerve fibers, and small blood vessels

A

RETICULAR FIBERS

61
Q

Form sparse networks interspersed with collagen bundles in many organs

Have physical properties to be stretched or distended and return to their original shape

Composite of fibrillin microfibrils embedded in a larger mass of cross- linked elastin.

A

ELASTIC FIBERS

62
Q

Highly hydrated, transparent, complex mixture of macromolecules, principally of three classes

A

GROUND SUBSTANCE

63
Q

GROUND SUBSTANCE

three classes:

A

glycosaminoglycans (GAGs) proteoglycans multiadhesive glycoproteins

64
Q

Fills the space between cells and fibers in connective tissue and, because it is viscous:
acts as both a lubricant and a barrier to the penetration of invaders

A

GROUND SUBSTANCE

65
Q

GLYCOSAMINOGLYCANS
Also called

A

mucopolysaccharides

66
Q

Long polysaccharides consisting of repeating disaccharide units, usually a uronic acid and a hexosamine

A

GLYCOSAMINOGLYCANS

67
Q

Largest and most ubiquitous GAG is

A

hyaluronic acid

68
Q

Composed of a core protein to which are covalently attached various numbers and combinations of the sulfated GAGs

Synthesized on RER, mature in the Golgi, where the GAG side chains are added

Example: Aggrecan, Decorin, Syndecan

A

PROTEOGLYCANS

69
Q

Large molecules with branched oligosaccharide chains and have important roles in the adhesion

Multiple binding sites for cell surface receptors (integrins)

A

MULTIADHESIVE GLYCOPROTEINS

70
Q
  • provides adhesion for epithelial and other cells, with binding sites for integrins, type IV collagen, and specific proteoglycans
A

Laminin

71
Q

As binding sites for collagens and certain GAGs, and forms insoluble fibrillar networks throughout connective tissue

Provides specific binding sites for integrins and is important both for cell adhesion and cellular migration through the ECM

A

Fibronectin

72
Q
  • act as matrix receptors for specific sequences on laminin, fibronectin, some collagens, and certain other ECM proteins

Cytoplasmic portions of integrins associate with the peripheral membrane proteins talin and vinculin, which together bind actin filaments

A

Integrin