exam 2 lecture 13 Flashcards
Gq examples
muscarinic acetylcholine receptors angiotensin II receptors
Gq mechanism
receptor binds and aBy binds, a binds to phospolipase C, brings in PIP2 and converts to IP3 and DAG, IP3 goes to the ER and DAG goes to protein kiase to phosphorylate then response
T/F IP3 opens gated ion channel
true
what is the the concentration gradient for in the ER
Ca2+
what hydrolyzes PIP2 to DAG and IP3
phospholipase C
cytoplasmic PKC-protein kinase C is inactive until what binds to it
Ca2+ and DAG
what is the ratio of free calcium inside to outside the cell
10^-7:10^-3 so 10^4
what happens when Caq is activated
Ca2+ is release from the ER
what maintains low levels of free calcium in the cytosol
active transport
CaM binds Ca2+ at what 2 ends
the 2 terminal domains-EF hands
binding to CaM exposes what
the hydrophobic surfaces
what is the likely KD of calmodulin (CaM)
10^-6 M
RTK means
receptor tyrosine kinase
RTK activates what
phosphatidylinositol 3 kinase- PI3K
T/F various phospholipases cleave different phospholipid and different substrate specificity
True
