exam 2 lecture 14 part 2 Flashcards
cascade effect outcomes
upregulation and/or downregulation resulting in production of cytokines
cascade effect increases the number of what and suppresses what
increase surface receptors and suppresses their own effect by feedback inhibition
macrophage release of what induced lymphocyte migration
chemokines
what produced antibodies
Bcell development and gene recombination
T/F expression of cytokine and cytokine receptors is highly regulated
true
what 3 pathways does the gamma chain activate
the PI 3-K-Akt pathway, the RAS-MAPK, and the JAK-STAT
the gamma chain regulates what
the development, survival, proliferation, differentiation and or function of multiple immune cell types
what shape is the IL-6
helical
IL-6 subunits
gamma chain, gp130 and the IL-6 R alpha chain
what secretes IL-6
macrophages and other cells
what does IL-6 stimulate
acute phase protein synthesis, production of neutrophils, regulates inflammation
what diseases are IL-6s involved in
rheumatoid arthritis, multiple sclerosis, systemic lupus, prostate cancer, and multiple myeloma
what role does IL-6 have in cancer
chronic inflammation and in regulating tumor microenvironments and metastasis
what drugs are progressing for anti-IL-6
taclizumab and sarilumab for rheumatoid arthritis
siluximab for castleman disease
what is thought to be a central mediator of physiologic changes induced by allergic inflammation
IL-13
