(III) Fastidious Gram Negative Rods (4) Bordetella spp.

Question 1

What is the vaccine for Pertussis?

Answer 1

DTaP

Question 2

Name the protein responsible for Pertussis’ ability to attach to human cells

Answer 2

Filamentous hemagglutinin

Question 3

MOA: Pertussis toxin

Answer 3

ADP Ribosylation of Gi ⇒ ↑ cAMP

Question 4

What is the effect of ↑ cAMP due to Pertussis toxin?

Answer 4

Lymphocytosis

Question 5

Name 3 toxins associated with Pertussis

Answer 5

(1) Pertussis toxin
(2) Adenylate cyclase toxin
(3) Tracheal toxin

(Trachea ∝ Tractor)

Question 6

What is the effect of Trachea toxin?

Answer 6

Damages ciliated respiratory epithelium

Question 7

Which phase of Pertussis has the characteristic whooping cough?

Answer 7

Paroxysmal

(Catarrhal → Paroxysmal → Convalescent)

Question 8

How long does the convalescent stage of Pertussis last?

Answer 8

Up to several months

Question 9

ROT: Pertussis

Answer 9

Respiratory droplets

Question 10

Treatment: Pertussis

Answer 10

Macrolides

(Macrolides are not as helpful once toxins are circulating)

Question 11

Bordetella pertussis infection

Transmission: […]

Classic Clinical Presentation:
[…]
- […]
- […]

Answer 11

Bordetella pertussis infection

Transmission: respiratory droplets

Classic Clinical Presentation:
whooping cough
- Catarrhal stage: resemble other respiratory infections (low-grade fever, runny nose, sneezing, mild cough. This is the most contagious stage)
- Paroxysmal stage: bursts of paroxysmal cough (lungs emptied in a series of 5-20 cough before inspiratory gasp through a narrowed throat which produces the ‘whoop’), once this stage is established, may persist for several months (convalescent stage)

“Pertussis means “violent cough.” Bordetella pertussis causes whooping cough”

Included in DTaP (Diptheria-Tetanus- acellular Pertussis) vaccine.

Tdap is the same, just that smaller letter = less amount of d and ap lol.