Ibuprofen (ANALGESIC DRUG)

Question 1

What is the pharmacokinetics for ibuprofen?

Answer 1

Administration: parental/enteral
Distribution: Plasma protein
Metabolism: liver
Excretion: uterine and in some faeces

Question 2

What type of drug is ibuprofen classed as

Answer 2

NSAID (nonsteroidal anti-inflammatory drug)

analgesic (relieves pain)

antipyretic (reduces temperature)

anti-inflammatory (reduces inflammation)

Question 3

What is a NSAID drug and what does this stand for

Answer 3

non-steroidal anti-inflammatory drug. This means NSAID drugs relive pain, reduce inflammation and lower temperatures.

Question 4

How is ibuprofen presented on the road

Answer 4

Solution: either 100mg in 5ml OR 20mg in 1ml

Tablets: 200mg OR 400mg

Question 5

What are the indications for ibuprofen

Answer 5

To relieve mild—> moderate pain

Pt with pyrexia (fever) WITH discomfort- helps to relieve other unpleasant symptoms that accompany febrile illness (fever) like aches and pains.

soft tissue injuries

Works best when used as a balanced analgesic plan (like with paracetamol)

Question 6

possible adverse effects with ibuprofen

Answer 6

Asthma (reaction)
Skin conditions
GI upset
Constipation
Diarrhoea
Dizziness
Fatigue
GI disorders
Haemorrhage
Headache
Inflammatory bowel disease
Insomnia
Oral disorder
Vertigo

JRCALC:
nausea/vomiting
tinnitus (ringing in ears)
Nausea

Question 7

what are the pharmacodynamics of ibuprofen

Answer 7

works on one of the body’s chemical pathways for pain

reduces the body’s ability to make prostaglandins (=natural chemicals that trigger pain, inflammation, and fever.

with reduced prostaglandins in the body, pain, and inflammation are reduced and fever goes down.

Question 8

what is the adult dosage for ibuprofen

Answer 8

Oral: 400mg every 8 hours
maximum of 1200mg per 24 hours (up to 3x per day after food)

Question 9

What are the contraindications for ibuprofen

Answer 9

dehydrated pt
hypovolaemic pt
renal insufficiency
active upper GI disturbance
The last trimester of pregnancy
children with chicken pox
previous hypertensive reaction
active peptic ulcer
severe heart, renal or hepatic failure
pt on anticoagulant medications (nonclotting drugs like warfarin)

Avoid NSAID drugs if other NSAID drugs have been administered 4 hours previously.

No NSAID drug for older adults with fractures
No NSAID drug for older adults who are frail.

Question 10

cautions for ibuprofen

Answer 10

Pt with asthma: due to possible risk of hypersensitivity and bronchoconstriction.
If pt hasn’t used NSAID drug previously don’t give it for the first time in the pre-hospital setting

Older pt: pt over 65 who haven’t had/tolerated NSAID drug recently

pt with coagulant defect (issues with clotting)

Crohn’s disease and ulcerative colitis as may worsen the condition

hypertension

pt with ischemic heart disease, peripheral arterial disease, cerebrovascular disease, congestive heart faliure.