methoxyflurane (ANALGESIC DRUG)

Question 1

What are the pharmacokinetics for methoxyflurane

Answer 1

administration: inhaled
distribution: plasma protein
metabolism: lung cells
excretion: exhalation

Question 2

What are the pharmacodynamics for methoxyflurane

Answer 2

methoxyflurane is an inhaled analgesic designed to be self-administered using a handheld device

can be used as a non-opioid alternative to morphine/ with morphine for very severe pain

believed to reduce pain signals across gap junctions

Question 3

possible side effects of methoxyflurane

Answer 3

dizziness
coughing
drowsiness
headache
nausea
hypotension
bradycardia

Question 4

how is methoxyflurane presented on the road

Answer 4

in a bottle of 3ml (inhaler)
vial of methocyflurane 99.9% inhalation vapour, liquid

Question 5

how is methoxyflurane administered

Answer 5

through a handheld inhaler

Question 6

what are the indications for methoxyflurane

Answer 6

relief of moderate to severe pain with trauma and associated pain

Question 7

what are the contraindications for methoxyflurane

Answer 7

pt under 18y/o
recent use of methoxyflurane ( over 15ml in the previous week)
known hypersensitivity to methoxyflurane/anesthetic gases
pt with liver damage/impairment
chronic kidney disease (stage 4 or 5)
altered LOC due to head injury, drugs or alcohol
cardiovascular instability (like heart faliure, hypotension or arrythmia)
reduced rr
history of severe adverse reaction to inhaled anaesthetic gas or malignant hyperthermia

Question 8

How long does inhaled methoxyflurane last for

Answer 8

25-35 mins

Question 9

what is the dosage of methoxyflurane

Answer 9

1 bottle of 3ml inhaled
maximum of 2 bottles (6ml) inhaled in 24 hours