Lect 4 Flashcards
what is ambisome used for
treatment for visceral leish
-it is a one shot treatment thing
-intravenous injection
-made by gilhead
what is post kala azar dermal leish
-pkdl
-10% of people who got cured after visceral leish
-looks like lil dots
-parasites are in low quantity on the skin
true or false: there is more asymptomatic cases than clinical cases
true it is like 5-20 cases for 1 clinical case
what is the immune response to leish
-activated dc activates CD4 t cells
-activate th1 cells
-get il2 and inf gamma
-activate macrophages and you have inos
-macropage kills parasite
what happens when you have leish and HIV
-no more cd4
-you get il4
-activates th2-get more il4
-activates B cells
-you get antibodies
-parasite survival
-shitty outcome
what does imiquimod do
activates TLRs 7/8 in phagolysosome
-ssrna is natural ligand for tlr 7/8
-you push for the best outcome
-it also activates macrophages for inos
what is aldara
-imiquimod topical cream
-treats cutaneosu leish
where are the parasites in the macrophages in leish
phagolysosome
true or false: imiquimod fucks up leish
true but depends on what it is used for
imiquimod % of slay
-increases rate of sucess with antimony
-around 72% to 75%
what is the % of slay of aldara
30%
what is the tlr 9 agonist
cpg currently in clinical trials to treat leish
imiquimod is also used for what other than leish
-slays against dengue
-when applied as a cream on skin after bite
-it activates macrophages
when was the cause of malaria discovered
-charles laveran
-in 1886
-found that it was a parasite cuz he was a slay at microscope
when did laveran win his nobel
in 1907
