Week 3 Pre-Learning: Other Manifestations of Cirrhosis Flashcards
1
Q
Why does jaundice occur in cirrhosis?
A
- Hepatic jaundice can occur due to damage of liver cells and intrahepatic cholestasis
2
Q
Why do infections occur with cirrhosis?
A
- Portal-systemic shunts (collateral circulation) created as a result of portal HTN allow ingested bacteria to bypass the liver
3
Q
Hepatorenal syndrome may occur with cirrhosis. What is that? (2)
A
- sudden decrease in urinary output
- elevated BUN and creatinine levels
- Increased urine osmolality
4
Q
Hormonal imbalances may occur with cirrhosis. Why? (2)
A
- Impaired breakdown of steroid hormones (ex. aldosterone, estrogen, testosterone)
- can cause water/Na+ retention, testicular atrophy, gynecomastia, amenorrhea, spider angiomas, palmar erythema. and abnormal hair growth
5
Q
Drug toxicity may occur with cirrhosis. Why?
A
- Impaired hepatocyte function can result in impaired clearance of drugs. This can cause elevated levels of drugs or metabolites in the blood, and can have toxic effects
6
Q
Cirrhosis of the liver Body Diagram*
A