Week 1 Pre-Class Learning: Glucose Regulation - Medications

Question 1

What are the two types of insulin sensitizers?

Answer 1

1. Biguanides (metformin)
2. TZDs (Rosiglitazone)

Question 2

What are the two types of Incretin Agents?

Answer 2

1. GLP 1 receptor agonists (Liraglutide)
2. DPP 4 Inhibitors (Sitagliptin)

Question 3

What are the two types of Insulin secretagogues? (2)

Answer 3

1. Sulfonylureas (Gliclazide)
2. Meglitinides (Repaglinide)

Question 4

What are the two types of miscellaneous (glucose wasters) anti-hyperglycemia medications?

Answer 4

1. SGLT 2 Inhibitors (Canagliflozin)
2. Alpha-Glucosidase Inhibitors (Acarbose)

Question 5

BIguanides drug card from slides. Answer the following:
- Drug name (Generic and brand)
- MOA (3)
- Indication
- Nursing considerations
- Therapeutic effect
- Adverse Effects (4)

Answer 5

Question 6

Thiazolidinediones (TZDs) drug card from the slides.
Answer the following:
- Drug name (Generic and brand)
- MOA (Primary and secondary)
- Indication
- Therapeutic effect
- Adverse Effects (3)

Answer 6

In class, TZD does not increase insulin secreted by pancreas

Question 7

GLP 1 Receptor Agonists Drug card from slides.
Answer the following:
- Drug name (Generic and brand)
- MOA!
- Indication
- Therapeutic effect (2)
- Adverse Effects (5)

Answer 7

Question 8

Are GLP 1 Receptor Agonists low risk? why or why not? (2)

Answer 8

they are low risk because they are glucose dependent
- needs an increase in blood glucose to secrete insulin

Question 9

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors (Gliptins) drug card from slides.
Answer the following:
- Drug name (Generic and brand)
- MOA (8)
- Indication
- Therapeutic effect
- Adverse Effects (3)

Answer 9

Question 10

DPP-4 Inhibitors Diagram from Class Notes

Answer 10

Question 11

Sulfonylureas drug card from slides. Answer the following:
Drug Name (generic and brand)
MOA
Indication
NC
Therapeutic Effect
Adverse Effects (2)

Answer 11

Alcohol consumption can POTENTIATE DIAMICRON

Question 12

Meglitinides Drug card from slides. Answer the following:
Drug Name (generic and brand)
MOA (2)
Indication
NC
Additional Information (3) Hint: peak
Adverse Effects (2)

Answer 12

Acts faster than sulfonylureas!

Question 13

Are Sulfonylureas glucose dependent?

Answer 13

No

Question 14

Why do medications like sulfonylureas cause weight gain?

Answer 14

insulin causes fluid retention

Question 15

Alpha Glucosidase Inhibitors Drug card. Answer the following:
- Drug name (generic and brand)
- MOA (2)
- Indication
- Therapeutic Effect (2)
- Additional Information (3)
Adverse Effects (3)

Answer 15

monitor liver enzymes every 3 months

Question 16

If someone taking acarbose is hypoglycemic, would you give them glucose or sucrose?

Answer 16

glucose because this medication delays absorption of carbs

Question 17

Sodium-Glucose Co-Transporter 2 (SGLT 2) Inhibitors Drug card from slides. Answer the following:
- Drug name (generic and brand)
- MOA (2)
- Indication
- Therapeutic Effect (2)
- Adverse Effects (4)

Answer 17

Be careful with using other diuretics!

Question 18

Why do SGLT 2 inhibitors cause dehydration?

Answer 18

It reduces reabsorption of glucose and increases urinary glucose excretion. Fluids try to dilute the glucose being excreted