Week 3 Pre-Learning: Other Manifestations of Cirrhosis

Question 1

Why does jaundice occur in cirrhosis?

Answer 1

• Hepatic jaundice can occur due to damage of liver cells and intrahepatic cholestasis

Question 2

Why do infections occur with cirrhosis?

Answer 2

• Portal-systemic shunts (collateral circulation) created as a result of portal HTN allow ingested bacteria to bypass the liver

Question 3

Hepatorenal syndrome may occur with cirrhosis. What is that? (2)

Answer 3

• sudden decrease in urinary output
• elevated BUN and creatinine levels
• Increased urine osmolality

Question 4

Hormonal imbalances may occur with cirrhosis. Why? (2)

Answer 4

1. Impaired breakdown of steroid hormones (ex. aldosterone, estrogen, testosterone)
   - can cause water/Na+ retention, testicular atrophy, gynecomastia, amenorrhea, spider angiomas, palmar erythema. and abnormal hair growth

Question 5

Drug toxicity may occur with cirrhosis. Why?

Answer 5

• Impaired hepatocyte function can result in impaired clearance of drugs. This can cause elevated levels of drugs or metabolites in the blood, and can have toxic effects

Question 6

Cirrhosis of the liver Body Diagram*

Answer 6