Pain, Inflammation, and Addiction Flashcards
What is the therapeutic use for Acetaminophen ?
- fever reduction (antipyretic)
- alleviate mild to moderate pain (analgesic)
What is the therapeutic use for Morphine ?
alleviate moderate to severe pain (analgesic)
What is an NSAID ?
nonsteroidals anti-inflammatory drug
- have an increased risk of MI (myocardial infarction/heart attack) and CVA (cerebrovascular accident/stroke) and GI adverse events
What is the therapeutic use for Naloxone ?
reverse effects of opioid use and overdose
What is the therapeutic use for Ibuprofen ?
- inflammation suppresion
- for gout and RA
- pain & fever
- diabetic neuropathy
What is the therapeutic use for Methotrexate ?
- decrease immune response to help lessen effects of RA
- decrease joint inflammation and damage caused by that inflammation
What is the therapeutic use for Allopurinol ?
to prevent gout attacks (not to decrease present flare-ups)
- decrease uric acid production
What is the max dose of Acetaminophen for healthy adults ?
4 g/day
- 4000mg/day
What is the max dose of Acetaminophen for older adults and liver disease pt’s ?
2 g/day
- 2000mg/day
What is the recommended dose of Acetaminophen for kids ?
take dose indicated on package
What is the max 24 hr dose of Ibuprofen ?
3.2 g/day
- 3200 mg/day
What is responsible for the trigger of inflammatory response ?
prostaglandins
What are the cardinal signs of inflammation ?
- redness
- edema
- pain
- swelling
- heat
- loss of function
NSAIDs can cause an increased risk of ?
- MI
- stroke
- serious GI adverse events (bleeding, ulceration, perforation)
What are some clinical manifestations of RA ?
- appears gradual over weeks or months
- swollen joints, warm to palpation
- rheumatoid nodules in joints, heart, and lungs
