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Revision > Drugs 2 > Flashcards

Drugs 2 Flashcards

1
Q

name an example of an anti - resorptive drug
(carries MRONJ risk)

A

denosumab

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2
Q

what is denosumab used to treat and what is its mechanism of action

A

oseteoporosis (MRONJ risk)

inhibits osteoclast formation

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3
Q

side effects of anti resorptive drugs e.g denosumab

A

increased infection risk
osteonecrosis
alopecia
sciatica
abdominal discomfort

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4
Q

name 2 examples of anti angiogenic drugs (MRONJ risk)

A

bevacizumab
aflibercept
sunitinib

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5
Q

what are anti angiogenic drugs used to treat and what is there mechanism of action

A

used for treating cancer

aim to restrict tumour revascularisation by inhibiting formation of new blood vessels

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6
Q

side effects of anti angiogenic drugs

A

osteonecrosis (MRONJ risk)
dry mouth
abscess
alopecia
anaemia
sepsis

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7
Q

name 2 examples of bisphosphonates

A

alendronic acid
ibandronic acid
zolendronic acid

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8
Q

what are bisphosphonates used to treat and what is there mechanism of action

A

treat osteoporosis

inhibit bone formation by inhibiting enzymes responsible for formation , recruitment and function of osteoclasts

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9
Q

side effects of bisphosphonates

A

alopecia
anaemia
osteonecrosis
altered taste
chills
fever
dysphagia

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10
Q

name 2 examples of proton pump inhibitors

A

omeprazole
lansoprazole

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11
Q

what are protein pump inhibitors used to treat and what is their mechanism of action

A

GIT ulceration, helicobacter pylori, GORD

inhibit gastric acid secretion

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12
Q

side effects of proton pump inhibitors

A

abdominal pain
constipation
diarrhoea
dry mouth
dizzyness

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13
Q

name 2 examples of antihistamines

A

loratadine
fexofenadine
cetirizine

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14
Q

antihistamines
- indication
- moa
- side effects

A
  • allergy relief
  • block effects of histamine
  • drowsiness
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15
Q

name 3 examples of opioid analgesics

A

tramadol
co codamol
codeine
fentanyl
morphine

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16
Q

how do opioid analgesics work

A

attatch to opioid receptors on nerve cells throughout body thereby blocking pain messages sent from body through spinal cord to brain

17
Q

side effects of opioid analgesics

A

addiction
withdrawal syndrome
respiratory depression
hallucinations
arrythmias
confusion
dry mouth

18
Q

what type of drug is warfarin

A

anticoagulant - vitamin K antagonist

19
Q

warfarin
- indications
- moa

A

atrial fibrillation, prosthetic valves, TA, embolism

antagonistic action against vitamin K therefore inhibits formation of factors 2,7,9,10

20
Q

side effects of warfarin

A

haemmhorage
nausea
vomiting
(many drug interactions)

Revision (19 decks)

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