Ciclosporin Flashcards
Immunosuppression therapy
1
Q
what is ciclosporin
A
calcineurin inhibitor which inhibits lymphokines which then suppresses cell-mediated response
2
Q
ciclosporin prescription requirement
A
prescribe by brand
3
Q
s/e of ciclosporin
A
- HYPER - gylcaemia, kalaemia, lipidaemia, tension, uricemia
- HYPO - magnesia
- renal/liver impairment
- givgival hyperplasia
- skin reactions
- hair changes
4
Q
who should avoid ciclosporin
A
in women who are pregnant or breast-feeding
5
Q
ciclosporin interactions
A
- grapefruit + pomelo juice = increase ciclosporin exposure
- purple grape juice = lowers ciclosporin exposure
6
Q
pre-screening requirement with ciclosporin
A
pre-screening exclude malignancies before systemic use
7
Q
ciclosporin monitoring requriments
A
- LFT
- Mg+,K+ and lipid levels
- CrCl
- BP
- trough = depends on indication
8
Q
what should be avoided with ciclosporin
A
exposure to UV light and sunlight
9
Q
what can EYE topical use of ciclosporin cause
A
eye inflmmation and visual disturbance which can affect driving and skilled task performances
