Mycophenolate Mofetil

Question 1

MoA of mycophenolate mofetil

Answer 1

inhibits purine synthesis

Question 2

s/e of mycophenolate mofetil

Answer 2

• bone marrow supression
• pure red cell aplasia
• hypogammaglobulinaemia
• bronchiestasis

Question 3

s/e of mycophenolate mofetil

symptoms to report if bone marrow supression

Answer 3

• infections
• bruising
• bleeding

Question 4

s/e of mycophenolate mofetil

what to do if pt develops pure red aplasia

Answer 4

reduce dose or discontinue

Question 5

s/e of mycophenolate mofetil

what levels need to be measured if pt develops hyopagammaglobulinaemia

Answer 5

measure immunoglobulin lvls in recurrent infection

Question 6

s/e of mycophenolate mofetil

symptoms of bronchiectasis

Answer 6

consider if persistent cough or SoB develop

Question 7

MHRA warning of mycophenolate mofetil

Answer 7

tetrogenic

Question 8

MHRA warning

contraception advise with mycophenolate mofetil

Answer 8

• women = 1 effective contraception during tx and 6wk after (2 methods ideal)
• men = effective contraception during and 90DY after tx (+partners)