Antiplatelets, Anticoagulants, Hypolipidemic Agents Flashcards

1
Q

An antiplatelet that is an irreversible COX inhibitor so that arachidonic acid will not form thromboxane
S/E: Hypersensitivity, hepatic encephalopathy and Reye’s syndrome, severe bleeding, NSAID-induced GIT irritation and peptic ulcer

A

Aspirin

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2
Q

GPIIB/IIIA antagonists

A

Abciximab, Tirofiban, Eptifibatide

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3
Q

P2Y12 antagonist

A

Clopidogrel, Ticlopidine

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4
Q

Phosphodiesterase inhibitor; it increases cAMP by inhibiting its degradation

A

Cilostazol
Dipyridamole

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5
Q

An anticoagulant drug that inhibits vitamin K-dependent clotting factors (IX, X, VII, II)

A

Warfarin

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6
Q

Anticoagulant drugs that are indirect thrombin inhibitor. They do not inhibit thrombin itself but instead, amplifies the actions of the anti-thrombin, specifically anti-thrombin III

A

Heparin
Fondaparinux

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7
Q

Anticoagulant drugs that are direct thrombin inhibitors

A

Dabigatran
Argatroban
Lepirudin

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8
Q

Anticoagulant drugs that are direct Xa inhibitors aka Novel Oral Anticoagulants (NOACs)

A

Apixaban
Rivaroxaban

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9
Q

Fibrinolytic agents that amplify the action of the t-Pa or tissue plasminogen activator

A

Streptokinase
Urokinase
Reteplase
Alteplase
Tenecteplase

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10
Q

Are used to inhibit the rate limiting step in the cholesterol synthesis which is the HMG-COA reductase. It primarily inhibits the synthesis of cholesterol. These drugs work at night so they should be given at night time, OD. They primarily have an effect of LDL lowering

These 2 drugs are under this classification but can be given in the morning because they have long half lives
A/E: Rhabdomyolysis and hepatotoxicity

A

HMG-COA reductase inhibitors
Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin, Pitavastatin

Atorvastatin and Rosuvastatin

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11
Q

Are also known as bile acid-binding resins. These drugs bind to the bile acids in the stomach for it to be excreted in the feces. They primarily have an effect on LDL lowering

A

Bile acid sequestrants
Cholestyramine, Colestipol

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12
Q

These drugs inhibit the absorption of cholesterol. They primarily have an effect on LDL lowering

A

Inhibitor of intestinal absorption of cholesterol
Stanol esters, Ezetimibe

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13
Q

Is a new class of drugs that inhibit the CETP enzyme, therefore inhibiting cholesterol transport

A

CETP inhibitors
Cholesterol ester transfer protein inhibitors
Torcetrapib, Anacetrapib

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14
Q

This drug inhibits the enzyme lipoprotein lipase. When this enzyme is inhibited, we lose the synthesis of free fatty acids. They have an effect primarily lowering the HDL
S/E: Flushing or cutaneous vasodilation

A

Niacin (Vitamin B3)

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15
Q

These drugs activate the PPAR-alpha in the liver wherein the gene expression for the cholesterol synthesis will be decreased. When they activate PPAR-alpha, it inhibits cholesterol synthesis. They have an effect of primarily lowering the triglycerides and the HDL
S/E: Gallstones formation (cholelithiasis), electrolyte imbalance (hypokalemia, hyponatremia but not common), rashes (not common)

A

Fenofibrate
Clofibrate, Gemfibrozil

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