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MICROBIOLOGÍA > rabia, ebola y priones > Flashcards

rabia, ebola y priones Flashcards

1
Q

ssRNA -
envuelto
Lyssavirus

A

Rabia

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2
Q

transmisión directa de la saliva a la sangre

A

rabia

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3
Q

proteinas del virus de la rabia

A
  • G
  • M
  • ribonucleoproteima (N, P y L)
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4
Q

antigeno mayor del virus de la rabia

A

proteia G

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5
Q

principal reservorio

A

murcielago

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6
Q

lugar en el que se replica el virus de la rabia

A

musculo y de ahi viaja al SNC

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7
Q

velocidad a la que el virus de la rabia viaja desde el lugar en el que entro hasta el SNC

A

5-10 cm/dia

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8
Q

unica oportunidad de vacunacion al ser infectado por rabioa

A

periodo de latencia

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9
Q

zonas a las que se disemina el virus de la rabia despues del SNC

A

glandulas salivales, cornea y nariz

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10
Q

cuadro clinico de rabia

A
  • incubabion de 6 dias a 2 años
  • periodo prodromico de 10 dias
  • rabia furiosa
  • rabia paralitica
  • 100% de mortalidad cuando aparecen los isntomas
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11
Q

rabia paralitica

A
  • no muy frecuente
  • es ascendente
  • se pouede confundir con GBS

GBS: Sx de Guillain-Barre

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12
Q

dx en vida de rabia

A
  • Prueba de Schneider
  • biopsia
  • serologia por LCR o sangre
  • PCR en LCR o saliva
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13
Q

caracteristico para el dx de rabia post-mortem

A

cuerpos de Negri

inclusiones eosinofilicas

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14
Q

ssRNA-
envuelto
Filovirus
forma filamentosa

`

A

Marbugvirus
Ebolavirus

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15
Q

transmision por contacto directo

A

ebolavirus

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16
Q

patogenia de ebolavirus

A
  • replicacion en monocitos, macrofagos y CD
  • tormenta de citocinas
  • lesion vascular y necrosis tisular
17
Q

epidemiologia de ebolavirus

A
  • endemico en Africa
  • DCR, sudan, Liberia, Sierra Leona, Guinea
18
Q

fiebre de Marburgo

A
  • brotes en Zimbabue y Kenia
  • laboratorio en Alemania
19
Q

cuadro clinico de ebolavirus

A
  • fiebre hemorragica
  • hay cuadros asintomaticos
  • 90% de mortalidad
  • cuadro prodromico flu-like
  • exantema
  • similar al cuadro de dengue grave
20
Q

dx de ebolavirus

A
  • BSL4
  • ELISA y PCR
21
Q

vacuna ebolavirus

A
  • 2019
  • recombinante
  • rVSV-ZEBOV (Ervebo)
22
Q

priones

A
  • no son virus
  • particula infecciosa
  • no anticuerpos
  • no respuesta inflamatoria
  • enfermedades neurodegenerativas
  • incubación de años
  • progresion inevitable
  • espongiforme
  • no hay tx

MICROBIOLOGÍA (28 decks)

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