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Flashcards in 16 Vasculitis Deck (20):
1

Giant Cell (Temporal) arteritis affects what group most commonly?

Over 50. Especially Northern Europeans.

2

Giant Cell (Temporal) arteritis affects which arteries?

temporal, vertebral, ophthalmic, aorta

[group as mostly "arteries of the head"]

3

T/F temporal arteritis can cause permanent blindness?

T. (ophthalmic artery)

4

Suspected etiology/pathogenesis temporal arteritis?

Unknown. Suspected: immune rxn against arterial wall protein, probably T-cell mediated (granulomatous)

5

Symptoms of temporal arteritis?

fever, fatigue, weight loss, abrupt diplopia or vision loss

[note most are non-specific]

6

Treatment temporal arteritis?

high-does anti-inflammatories (steroids)

7

Risk factors: Takayasu arteritis? (2)

-female under 40 (8:1, f:m)
-HLA -A24, B52, DR2

8

Incidence: Takayasu arteritis? (2)

-US: 1/1000
-Asia: 6/1000

9

Giant Cell (Takayasu) arteritis: affects what body parts? (3) How?

-Ascending aorta "Pulseless disease"
-Can also involve pulmonary & renal arteries
-Fibrosis of artery wall ->stenosis-> occlusion->dilation-> aneurysm

10

Giant cell (Takaysu) arteritis: signs early & late phases?

-Early: fever, arthalgias, weight loss, "prepulseless"
-Late: "Pulseless"

11

Type 1 Takayasu Arteritis is?

branchiocephalic trunk, carotid arteries & subclavian

12

Type 2 Takayasu Arteritis is?

combined Type 1 & Type 3

13

Type 3 Takayasu Arteritis is?

"atypical coarctation type" involves thoracic & abdominal aorta (most common!!)

14

Type 4 Takayasu Arteritis is?

"Dilated type", dilation of aorta & its major branches

15

Takayasu arteritis: treatment? (2)

-steroids
-angioplasty (after acute phase)

16

Thromboangitis obliterans (Buerger's disease): Risk factors? (3)

-Japan or Near East descent
-Smoking
-HLA-A9, HLA-B5

17

Thromboangitis obliterans: etiology, pathogenesis? (3)

-Endothelial damage
-Hypersensitivity to tobacco extract
-Result: acute & chronic vasculitis of medium & small arteries, esp radial & tibial. -> Ulceration of fingers & toes

18

Thromboangitis obliterans: treatment?

Quit smoking!

19

Wegener's granulomatosis: risk factors?

-Any age, sex, race, but mostly whites w/ slightly more males
-Age 41 median onset

20

Wegener's granulomatosis: etiology, pathogenesis?

-Unknown. Suspected: Hypersensitivity rxn initially
-Necrotizing granulomatous vasculitis
-Focal segmental glomerular nephritis
-Necrotizing vasculitis of median & small vessels