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Flashcards in 6 Intro to PNS Deck (38):
1

T/F peripheral nervous sys. is both autonomic and somatic?

T.

2

Sympathetics exit the CNS at what levels?

T1-L3

3

Parasympathetics exit the CNS at what levels?

CN 3,7,9,10 and S2-S4 (sacral)

4

Sympa or Parasympa has which of the following? -myelinated preganglionics -peripheral ganglia -unmyelinated postganglionics -Postganglionic transmission sites are on sm. muscle, gland cells & cardiac muscle

Both have all

5

T/F Somatic nervous sys. has ganglia in the periphery?

F. (all in CNS)

6

T/F There are unmyelinated somatic nerves?

F.

7

The tissues of WHICH system can continue functioning independent of innervation? (autonomic or somatic)

autonomic

8

Describe neurotransmitter release & reception

Made -> Put in vesicles -> Ca2+ up -> Released-> diffuse ->Hit receptor ->Diffuse or degrade

9

ACh or NE (acetylcholine or norepinephrine) is released by most postganglionic sympathetics?

NE. [ACh for all preganglionic & postganglionic parasympa]

10

Which system uses dopamine?

Postganglionic sympathetic

11

Name ACh receptor subclasses? (parasympa)

Nicotinic: N1 N2 Muscarinic: M1 M2 M3 M4

12

AChE (acetylcholinesterase) does what? Where?

destroys ACh at synapses. In body, (plasma, liver, glial cells, satellite cells)

13

Where are the following receptors found? N1

N1-sympa, parasympa ganglia [Note N1 is equally sensitive to agonists and antagonists]

14

Name NE (norepinephrine) receptor subclasses? (sympa)

-Alpha1 -Alpha2 -Beta1 -Beta2

15

Mechanism, function, location: alpha 1 receptor?

-G protein coupled -activates phospholipase C -smooth muscle contract (ex, sweat glands)

16

Mechanism, function, location: alpha 2 receptor?

-G protein coupled -inactivates adenylate cyclase -postganglionic sympa terminals & presynaptic adrenergic nerve terminals

17

Mechanism, function, location: Beta 1 receptor?

-G protein coupled -activates adenylate cyclase -cardiac muscle, presynaptic adrenergic & cholinergic terminals

18

Mechanism, function, location: Beta 2 receptor?

-G protein coupled -activates adenylate cyclase -smooth & cardiac muscle

19

Dopamine is used where in the peripheral nervous system? Give 1 example

-SOME postganglionic sympathetics -Postjunctional renal vascular sm. muscle

20

Where are the following receptors found? N2

N2-neuromuscular junction

21

Where are the following receptors found? M1

M1-ganglia, secretory glands

22

Where are the following receptors found? M2

M2-smooth & cardiac muscle, sweat glands

23

Where are the following receptors found? M3, M4

M3, M4- smooth muscle, secretory glands

24

Sweat glands are special in innervation... why?

sympathetic innervation, but 1/2 are ACh ("cholinergic sympathetic" muscarinic receptors), 1/2 are NE. [Know this!]

25

Adrenal medulla innervation is special... why?

Modified Sympathetic GANGLIONIC innervation, but use ACh as the neurotransmitter, w/ NO POSTGANGLIONIC fibers.

26

Which 5 body locations have only sympathetics?

Blood vessels Sweat glands Liver Spleen Adrenal gland

27

T/F motor axons are myelinated?

T

28

All somatic nerves have what kind of neurotransmitter? What kind of receptor?

-ACh -Nicotinic

29

ChAT enzyme does what?

Combines AcCoa and Choline

30

VAT transporter does what?

package ACh in vesicles

31

T/G ACh neurons can stimulate themselves by releasing ACh?

T

32

What triggers Ca2+ influx at a nerve terminal?

depolarization

33

What kind of machinery causes vesicles to fuse w/ membrane & exocyose their contents?

protein-protein interactions

34

In summary where is ACh mostly used?

all preganglionic, all postganglionic parasympa, 1/2 of sweat gland sympathetics, all somatic nerves

35

In summary where is NE used?

postganglionic sympathetic

36

What is a co-transmitter's function? (3)

-Hasten/slow action of primary neurotransmitter -provide feedback inhibition -main transmitter in non-ACh, non-NE nerves

37

Name the co-transmitters? (8)

-purines (adenosine, ATP) -peptides (cholecystokinin, somatostatin, substance P, neuropeptide Y, vasoactive intestinal peptide) -NO (nitric oxide)

38

How does adrenal medulla react when stimulated?

chromaffin cells release epinephrine and norepinephrine (NE) into blood (80% Epi)