Parker Study Guide Pg 1 Flashcards

1
Q
  1. What hormones have increased release during menopause?
A

FSH and Estrone (E1)

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2
Q
  1. What hormones have decreased release during menopause?
A

Inhibin and E2 (Estradiol)

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3
Q

Which of the three estrogens is not necessary for most adults, but pharmacies love it due to the money that can be made from it?

A

E3 - Estriol

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4
Q
  1. What are three short term complications of menopause?
A
  1. Hot flushes (vasomotor instability - E withdrawal - narrowing of thermoreg. zone -> increase sensitivity to temp changes)
  2. Mood changes
  3. Atrophy of urogenital tissues (estrogen or other meds)
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5
Q
  1. What are three long term consequences of menopause?
A
  1. Increased cardiovascular disease
  2. Fat redistritubion
  3. Osteoporosis
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6
Q
  1. What are three treatments for the long term consequence of osteoporosis?
A

Bisphosphates and Calcium, vitamin D, and Estrogen

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7
Q
  1. What are the dental concerns for women with osteoporosis?

- What are the concerns for them regarding the use of bisphosphates?

A
  • Loosening of teeth
  • Jaw osteonecrosis (from bisphosphates)
  • Burning mouth syndrome
  • Gingivostomatitis or atrophic gingivitis resulting from drying of the oral tissues
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8
Q
  1. What kind of treatment may be recommended for postmenopausal women with gingival bleeding and risk of tooth loss?
A

Estrogen replacement therapy - associated with less gingival bleeding and may be beneficial in preventing tooth loss

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9
Q
  1. What are the 2014 hormone replacement therapy recommendations?
A
  1. Use lowest dose for the shortest time
  2. Have other medication options for host flushes and other symptoms
  3. Keep ongoing surveillance for osteoporosis and oral health
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10
Q
  1. List the three types of estrogen in decreasing potency
A

Estradiol (E2) > Estrone (E1)> Estriol (E3)

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11
Q
  1. Which of the three types of estrogen is the primary hormone before menopause?
A

Estradiol (E2)

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12
Q
  1. Which of the three types of estrogen is the primary hormone after menopause?
    - Where is it found?
A

Estrone (E1)

Found in fat cells

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13
Q
  1. Which of the three types of estrogen is made by the placenta and is not necessary in adults?
A

Estriol (E3)

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14
Q
  1. What are two benefits of hormone replacement therapy?
A

Decreases bone fractures and risk of colon cancer

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15
Q
  1. What are two negatives of hormone replacement therapy?
A
Increased breast / endometrial cancer
Blood clots (Deep Vein Thrombosis)
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16
Q
  1. What are the three forms of combined contraceptive options?
A
  1. Contraceptive pills
  2. Vaginal ring
  3. Transdermal

(Estrogen + Progesterone)

17
Q
  1. What are two contraindications for usage of combined contraception?
A
  1. Cancer

2. Blood clots (deep vein thrombosis)

18
Q
  1. What is the medical eligibility criteria for contraceptive use for each of the combined contraceptive options?
A
  1. Contraceptive pills - daily for three weeks, placebo for one week
  2. Ring - three weeks ring in, one week out
  3. Patch - Apply one patch a week for three weeks, then one week no patches
19
Q
  1. What are the two mechanisms of action for estrogen’s contraception use?
A
  1. Builds endometrial lining

2. Suppresses FSH to interfere with the development of the dominant follicle

20
Q
  1. What is the mechanism of action for progesterone only contraception?
A
  1. Thickens cervical mucus
  2. Impairs mobility in fallopian tube
  3. Delays or prevents LH surge and ovulation (via suppression of GnRH)
21
Q
  1. What are three forms of progestin only contraception?
A
  1. Pills
  2. Depo Provera
  3. Implant
22
Q
  1. Progestin-Only Contraceptive pills
    - Ovulation suppression rate vs COC’s?
    - Break weak?
    - This option is great for nursing and women with a contraindication towards what hormone?
A
  1. 57% ovulation suppression for POCs vs 95% for COCs
  2. No break weak due to very low serum conc.
  3. Good for nursing and women with estrogen contraindications
23
Q
  1. Depo Provera injection
    - How often is it administered?
    - What are three risks?
A
  1. Administered every three months

2. Increased weight, irregular bleeding, and possible risk for loss of bone density

24
Q
  1. Implant - Intradermal progestin-only contraception

- Effective for how long?

A

3 years

25
Q
  1. Implant - Intrauterine Progestin-only contraception - Mirena
    - Effective for how long?
    - Useful not only for contraception, but also reduces heavy _____
    - Not to be used for what purpose?
    - Advised not to insert IUD if what is present?
A
  • Effective for five years
  • Useful in reducing heavy bleeding
  • Not to be used as an emergency contraceptive
  • Advised not to insert if STI’s present