19. Ab-Mediated Tissue Damage and Diseases Flashcards Preview

HDID 1 > 19. Ab-Mediated Tissue Damage and Diseases > Flashcards

Flashcards in 19. Ab-Mediated Tissue Damage and Diseases Deck (33)
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31

serum sickness

type III hypersensitivity

target antigen: various protein antigens

- systemic vasculitis, nephritis, arthritis

32

PAN (polyarteritis nodosa)

type III hypersensitivity

target antigen: HBV

- vasculitis

33

treatment of chronic hypersensitivity diseases

- agents that limit inflamm (corticosteroids)

- plasmapheresis to reduce levels of circulating disease-causing antibodies and immune complexes in severe cases

- IVIg to suppress Ab production by inducing the expression of inhibitor FcgammaRIIB (on mast cells) and binding to it...inhibit IgE via anti-idiotypic antibodies and facilitate removal from the body....may reduce IL-4

- immunotherapeutic approaches in trial now: block of CD40L to inhibit B-Tcell interactions, tolerance induction to allergens, control of Ab production by depletion of B cells by anti-CD20 Ab, induction of Treg cells