Furosemide

Question 1

Furosemide (Lasix)

Class

Answer 1

• Loop diuretic
• (For high pressure cardiac pulmonary edema)

Question 2

Furosemide (Lasix)

Mechanism of action

Answer 2

• Inhibits electrolyte reabsorption
• Promotes excretion of sodium, potassium, and chloride

Question 3

Furosemide (Lasix)

Indications

Answer 3

• CHF
• Pulmonary edema
• Hypertension crisis

Question 4

Furosemide (Lasix)

Contraindications

Answer 4

• Hypovolemia
• Hypotension (relative contraindication)
• Allergic
• Anuria
• Hepatic coma

Question 5

Furosemide (Lasix)

Adverse reactions

Answer 5

• May exacerbate:
• hypovolemia
• hypokalemia
• hypochloremia
• hyponatremia
• ECG changes
• dry mouth
• hyperglycemia (due to hemoconcentration)

Question 6

Furosemide (Lasix)

Drug interactions

Answer 6

• Lithium toxicity may be potentiated by sodium depletion
• Digitalis toxicity may be potentiated by potassium depletion

Question 7

Furosemide (Lasix)

Dosage and administration

Answer 7

• Adult:
  
  • 0.5 - 1.0 mg/kg injected IV over 1-2 minutes
  • If no response, double the dose to 2 mg/kg
• Pediatric:
  
  • 1 mg/kg/dose IV, IO

Question 8

Furosemide (Lasix)

Duration of action

Answer 8

• Onset: 5 min
• Peak effects: 20-60 min
• Duration: 4-6 hrs

Question 9

Furosemide (Lasix)

Special considerations

Answer 9

• Pregnancy: Cagetory C
• Rapid push can cause ototoxicity and deafness
• Protect from light