Dopamine

Question 1

Dopamine

Class

Answer 1

• Sympathomimetic
• Inotropic agent

Question 2

Dopamine

MOA

Answer 2

• Immediate metabolic precursor to norepi
• Increases systemic vascular resistance
• Dilates renal and splanchnic vasculature
• Increases myocardial contractility and stroke volume

Question 3

Dopamine

Indications

Answer 3

• Cardiogenic shock
• Septic shock
• Spinal shock
• Hypotension with low cardiac output states

Question 4

Dopamine

Contraindications

Answer 4

• VF
• Tachyarrhythmias
• Hypovolemic shock
• Phechromocytoma (tumor of adrenal glands)

Question 5

Dopamine

Adverse reactions

Answer 5

• Cardiac arrhythmias
• HTN
• Increased myocardial O2 demand
• Extravasation may cause tissue necrosis

Question 6

Dopamine

Drug interactions

Answer 6

• Incompatible in alkaline solutions
• MAOIs enhance effects
• Bretylium may potentiate effect (antiarrythmic)
• Beta-blockers may antagonize effects
• When administered with phenytoin (sz) may cause:
  
  • hypotension
  • bradycardia
  • sz

Question 7

Dopamine

Dosage

Answer 7

• Adult & Ped: 2-20 µg/kg/min, titrate for effect
• Dopaminergic response: (dilates vessels in kidneys; increased urine output): 2-4µg/kg/min
• ​Beta-adrenergic response: (positive chronotropic & inotropic): ​4-10µg/kg/min
• **Alpha stimulant/vasoconstict: **10-20µg/kg/min
• Reverse renal effects/override alpha effects: > 20 µg/kg/min

Question 8

Dopamine

Duration of action

Answer 8

• Onset: 1-4 min
• Peak: 5-10 min
• Duration: effects cease almost immediately after infusion is shut off

Question 9

Dopamine

Special considerations

Answer 9

• Preg Cat: C
• Effects are dose dependant
• Avoid extravasation
• Always monitor drip rate