1B CNS: Depression

Question 1

theories of depression (3)

Answer 1

amine hypothesis
neutrophic hypothesis
endocrine factors

Question 2

Neurotransmitter of Wakefulness and Mania

Answer 2

noradrenaline

Question 3

Neurotransmitter of Sleep, Mood, Feeding & Appetite

Answer 3

serotonin

Question 4

block the reuptake of serotonin and norepinephrine in presynaptic terminals, which
leads to increased concentration of these neurotransmitters in the synaptic cleft

Answer 4

TCA

Question 5

act as competitive antagonists on post-synaptic alpha (alpha1 and alpha2),
cholinergic muscarinic, and histaminergic receptor

Answer 5

TCA

Question 6

mitochondrial enzyme involved in the oxidative deamination of biogenic amines (Adr, NA, DA,
5-HT).

Answer 6

MAO

Question 7

Preferentially deaminates 5-HT and NA,

Answer 7

MAO A

Question 8

Preferentially deaminates phenylethylamine

Answer 8

MAO B

Question 9

It is a reversible and selective MAO-A inhibitor with short duration of
action; full MAO activity is restored within 1–2 days of stopping the drug.

Answer 9

Moclobemide

Question 10

This tetracyclic compound is unusual in that it blocks
dopamine D2 receptors in addition to inhibiting NA
reuptake.

Answer 10

AMOXAPINE

Question 11

This is a newer selective NA reuptake blocker with weak effect
on 5-HT reuptake

Answer 11

REBOXETINE

Question 12

A bicyclic compound, is the first SSRI to be introduced, and the longest acting.
► Its plasma t½ is 2 days and that of its active demethylated metabolite is 7–10 days.

Answer 12

FLUOXETINE

Question 13

It is a shorter-acting SSRI with a t½ of 18 hours and no active metabolite,
which has been specifically recommended for generalized anxiety
disorder and OCD, rather than for depression

Answer 13

FLUVOXAMINE

Question 14

It is a shorter-acting SSRI with a t½ of 18 hours and no active metabolite,
which has been specifically recommended for generalized anxiety
disorder and OCD, rather than for depression.

Answer 14

FLUVOXAMINE

Question 15

Efficacy in juvenile depression has been demonstrated, and it is
recommended for anxiety and post-traumatic stress disorder (PTSD) as
well.

Answer 15

SERTRALINE

Question 16

This SSRI shares with sertraline a lower propensity to cause drug
interactions. Its t½ is 33 hours and no active metabolite is known.
► However, few deaths due to overdose of citalopram are on

Answer 16

CITALOPRAM

Question 17

An SSRI indicated for premature ejaculation

Answer 17

DAPOXETINE

Question 18

1st choice drugs for OCD, panic disorder,
social phobia, eating disorders, premenstrual dysphoric disorder
and PTSD

Answer 18

SSRI

Question 19

novel antidepressant referred to as SNRI, because it inhibits uptake of both NA and 5-HT but, in contrast
to older TCAs, does not interact with cholinergic, adrenergic or histaminergic receptors or have sedative
propert

Answer 19

VENLAFAXINE

Question 20

A newer SNRI similar to venlafaxine. It is neither sedative, nor anticholinergic, nor antihistaminic, nor α
blocker

Answer 20

DULOXETINE

Question 21

It is the first atypical antidepressant; less efficiently blocks 5-HT uptake and has prominent α
adrenergic and weak 5-HT2 antagonistic actions

Answer 21

TRAZODONE

Question 22

is unique in not inhibiting either NA or 5-HT uptake; but blocks
presynaptic α2 receptors thereby increasing release and turnover of NA in
brain which may be responsible for the antidepressant effect.

Answer 22

MIANSERIN

Question 23

This inhibitor of DA and NA uptake has excitant rather than sedative propert

Answer 23

BUPROPION

Question 24

This antidepressant is reported to increase rather than inhibit
5-HT uptake, and is neither sedative nor stimulant.

Answer 24

TIANEPTINE

Question 25

The only antidepressants clearly shown to be effective in juvenile depression

Answer 25

fluoxetine and sertraline

Question 26

well tolerated option for mild to moderate depression, especially suited for elderly and cardiac patients

Answer 26

Moclobemide

Question 27

DOC for OCD

Answer 27

fluvoxamine

Question 28

reduces intensity of post-herpetic neuralgia in ~50% patients.

Answer 28

Amitriptyline

Question 29

a SNRI, is now a first line drug for diabetic neuropathy, fibromyalgia

Answer 29

Duloxetine

Question 30

a NA reuptake inhibitor unrelated to both TCAs as well as amphetamine, which is used specifically in ADHD.

Answer 30

Atomoxetine

Question 31

a SSRI which has been specifically introduced foR premature ejaculation

Answer 31

Dapoxetine

Question 32

In children above 5 years, this drug given at bedtime is effective, but bed wetting may again start when the drug is stopped.

Answer 32

imipramine (enuresis)

Question 33

prophylaxis for migrainre

Answer 33

amitriptyline, doxepine

Question 34

has been used to relieve itching in atopic dermatitis, lichen simplex

Answer 34

Topical doxepin

Question 35

antidepressants

Answer 35

MAOI TCA SSRI SNRI ATypicl