2.02 Disease Of Immunity

Question 1

Substances produced by T lymphocytes in cell-mediates immunity

Answer 1

Cytokines and leukotrienes

Question 2

T lymphocytes are found in the ___ areas of the lymph nodes and in the __ areas of the spleen

Answer 2

Paracortical areas of lymph node

Peroarterioler areas of the spleen

Question 3

Surface markers present in suppressor T cells

Answer 3

Pan T markers: CD3,2,5

Question 4

Subtype of helper t cells that stimulate production of most opsonizing and complement fixing bodies

Answer 4

TH1

Question 5

Subtype of t helper cells that secrete cytokines that stimulate the production of IgE and activate eosinophils

Answer 5

TH2

Question 6

Major cytokine that activates macrophages

Answer 6

Interferon

Question 7

what is the most important APC for initiating prinary immune response

Answer 7

Dendritic cells

Question 8

What are immature dendritic cells within the epidermis

Answer 8

Langerhans cells

Question 9

Receptors and MHC class of helper t cells

Answer 9

CD4

MHC Class II

Question 10

What is the major cytokine that activates macrophages

Answer 10

Interferon

Question 11

What is the most important antigen presenting cell

Answer 11

Dendritic cells

Question 12

Morphologic name of NK cells

Answer 12

Large granular lymphocytes

Question 13

Cell surface molecules in NK cells that gives the ability to lyse IgG coated target cells

Answer 13

CD16 cell surface molecules

Question 14

Adaptive immunity that acts in intracellular microbes

Answer 14

Cell mediated immunity

Question 15

__ immunity develops responses to soluble antigens

Answer 15

Humoral immunity

Question 16

__ immunity develops responses to insoluble antigens

Answer 16

Cell mediated immunity / cellular immunity

Question 17

What cytokine activates and initiates proliferation of naive T cells

Answer 17

IL-2

Question 18

What is the critical event in anaphylaxis that leads to degranulation of the maat cell

Answer 18

Bridging of IgE

Question 19

Most potent eosinophil activator (interleukin)

Answer 19

IL-5

Question 20

___ immunity develops a response to soluble antigens

Answer 20

Humoral immunity

Question 21

__ immunity develops a response to insoluble antigens

Answer 21

Cellular immunity (cell-mediated immunity)

Question 22

What cytokine initiates the activation and proliferation of T cells

Answer 22

IL-2

Question 23

What kind of test would you request if you are asking for MHC Class I?

Answer 23

Simple serologic assay

Question 24

What kind of test would you request if you are asking for MHC class II?

Answer 24

Mixed lymphocyte assay

Question 25

SLE is associated with HLA __ and __

Answer 25

HLA Dr-2 | HLA Dr-3

Question 26

Drugs that can produce drug-induced SLE

Answer 26

Procainamide Hydralazine Isoniazid D-Panicillamine

Question 27

The benign form of progressive systemic sclerosis

Answer 27

Limited scleroderma or CREST syndrome

Question 28

CREST Syndrome is serologically suggested by presence of

Answer 28

Anti-centromere antibodies

Question 29

Features of CREST syndrome

Answer 29

``` Calcinosis Reynaud's phenomenon Esophageal dysmotility Sclerodactyly Telangiectasis ```

Question 30

Main microscopic feature jn scleroderma

Answer 30

Fibrosis

Question 31

Antibody specific for diffuse scleroderma

Answer 31

Scl-70

Question 32

Pathognomonic sign in poliomyosistis-dermatomyosistis

Answer 32

Heliotropic rash

Question 33

Most specific antibody for Sjorgen's syndrome

Answer 33

Anti-SS-A | Anti-SS-B

Question 34

Anatomic structures that may be aplastic or hypoplastic in DiGeorge syndrome

Answer 34

Thymus Parathyroid Great vessels Esophagus

Question 35

___ immunity develops a response to soluble antigens

Answer 35

Humoral immunity

Question 36

__ immunity develops a response to insoluble antigens

Answer 36

Cellular immunity (cell-mediated immunity)

Question 37

What cytokine initiates the activation and proliferation of T cells

Answer 37

IL-2

Question 38

Triad of features of ataxia telangiectasia

Answer 38

Cerebellar ataxia Mucocutaneous telangiectasias Recurrent respiratory tract infections

Question 39

Where is the genetic defect located in Ataxia Telangiectasia

Answer 39

Long arm of chromosome 11