Vasopressin (Pitressin)

Question 1

Vasopressin classification

Answer 1

Hormone/vasopressor

Question 2

Vasopressin mechanism

Answer 2

V1R agonist -> Works on VSMC, by 2nd messenger with G-Proteins causing a cascade of reactions leading to the release of Ca2+ from sarcoplasmic reticulum. Increased Ca2+ -> sustained contractions by VSMC -> vasoconstriction

Question 3

Vasopressin pharmacokinetics

Answer 3

Onset: Varies
Peak Effects: Varies
Duration: 30-60min
Half Life: 10-20min

Question 4

Vasopressin indications

Answer 4

Cardiac Arrest

Question 5

Vasopressin contraindications

Answer 5

none in cardiac arrest

Question 6

Vasopressin side effects/adverse reactions

Answer 6

minor dysrhythmias, blanching of skin, abd cramps, htn, bradycardia

Question 7

Vasopressin Dose

Answer 7

Adult:
40 units iv io single dose only, to replace 1st or 2nd dose of Epi

Pedi: Not for pediatrics

Question 8

Vasopressin precautions

Answer 8

May cause vasoconstriction of coronary arteries, increase myocardial O2 demand

Question 9

Vasopressin drug interactions

Answer 9

None in ACLS