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Drug Cards > Promethazine (Phenergan) > Flashcards

Promethazine (Phenergan) Flashcards

1
Q

Promethazine Classification

A

Antiemetic/Anticholinergic

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2
Q

Promethazine Mechanism

A

H1 (Histamine) R and muscarinic ACh antagonist ->inhibits communication from the chemoreceptor trigger zone (which recognizes emetic toxins) to the vomiting center of the brain

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3
Q

Promethazine Pharmacokinetics

A

Onset: 5m IV, 20m IM
Peak: varies
Duration: 4-6h
Half Life: 10-14h

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4
Q

Promethazine Indications

A

Nausea/Vomiting

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5
Q

Promethazine Contraindications

A

Hypersensitivity

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6
Q

Promethazine Side Effects/Adverse Reactions

A

Drowsiness, sedation, blurred vision, tachycardia, bradycardia, dizziness

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7
Q

Promethazine Dose

A

Adult:
12.5-25mg IV IM
Pedi:
0.5mg/kg

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8
Q

Promethazine Precautions

A

May cause CNS depression or dystonia

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9
Q

Promethazine Drug Interactions

A
  • Potentiates CNS depressant effect of narcotics, sedatives/hypnotics, and EtOH
  • Increased incidence of dystonia with concurrnet use of MAOI
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