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Drug Cards > Ondansetron (Zofran) > Flashcards

Ondansetron (Zofran) Flashcards

1
Q

Ondansetron Classification

A

Antiemetic

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2
Q

Ondansetron Mechanism

A

5HT3 (Seratonin) R antagonist -> blocks seratonin binding to receptors at vagal nerve terminals -> inhibits vomiting reflex

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3
Q

Ondansetron Pharmacokinetics

A

Onset: Rapid
Peak Effects: 15-30m
Duration: 4-8h
Half Life: 4h

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4
Q

Ondansetron Indications

A

Nausea/Vomiting

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5
Q

Ondansetron Contraindications

A

Hypersensitivity

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6
Q

Ondansetron Side Effects/Adverse Reactions

A

HA, dizziness, tachycardia, prolonged QT intervals

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7
Q

Ondansetron Dose

A

Adult:
4mg slow IV IO, may repeat once

Pedi:
0.1mg/kg (max 4mg) slow IV IO

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8
Q

Ondansetron Precautions

A

Lower risk of sedation and dystonia than other antiemetics

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9
Q

Ondansetron Drug Interactions

A

Few in EMS

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