Vecuronium (Norcuran)

Question 1

Vecuronium Classification

Answer 1

Non-depolarizing neuromuscular blocker

Question 2

Vecuronium Mechanisim of Action

Answer 2

Nicotinic ACh R-antagonist -> competes with ACh at neuromuscular junction and prevents binding thus inhibiting skeletlal muscle depolarization

Question 3

Vecuronium Pharmacokinetics

Answer 3

Onset: <1m
Peak: 3-5m
Duration: 30-80m
Half Life: 30-80m

Question 4

Vecuronium Indications/Field Use

Answer 4

• Need for temporary paralysis to facilitate endotracheal intubation
• Need for continued paralysis following endotracheal intubation

Question 5

Vecuronium Contraindications

Answer 5

Hypersensitivity

Question 6

Vecuronium Side Effects/Adverse Reactions

Answer 6

Bradycardia, hypotension

Question 7

Vecuronium Dose

Answer 7

Adult:
0.08-0.1mg/kg IV, IO
Pedi:
0.1mg/kg IV, IO

Question 8

Vecuronium Precautions

Answer 8

Presence of neuromuscular diseases may be associated with prolonged paralysis

Question 9

Vecuronium Drug Interactions

Answer 9

Potentiated by lidocaine, procainamide, β-blockers, magnesium sulfate, and other neuromuscular blockers