Exotoxins

Question 1

Inactivate EF-2

Answer 1

Diphtheria toxin and Pseudomonas Exotoxin A

Question 2

Inhibit protein synthesis

Answer 2

Diphtheria toxin, Pseudomonas Exotoxin A, Shiga toxin, and Shiga-like toxin of EHEC

Question 3

Inactivate 60S Ribosome

Answer 3

Shiga and Shiga-like toxin

Question 4

Increase fluid secretion

Answer 4

ETEC Heat-labile and Heat-stable toxins, Bacillus anthracis Edema factor and Cholera toxin

Question 5

Overactivate adenylate cyclase, therefore increasing cAMP leading to Chloride secretion into the gut

Answer 5

ETEC Heat Labile toxin and Cholera toxin

Question 6

Overactivates guanylate cyclase, increasing cGMP and decreasing NaCl reabsorption

Answer 6

ETEC Heat Stable toxin

Question 7

Mimics adenylate cyclase enzyme, increasing cAMP

Answer 7

Bacillus anthracis Edema factor

Question 8

Inhibits phagocytosis

Answer 8

Pertussis toxin

Question 9

Disables Gi leading to increased cAMP

Answer 9

Pertussis toxin

Question 10

Inhibits neurotransmitter relase

Answer 10

Tetanospasmin and Botulinum toxin

Question 11

Proteases that cleave SNARE proteins

Answer 11

Tetanospasmin and Botulinum toxin

Question 12

Toxins that lyse cell membranes

Answer 12

C. perfringens Alpha toxin and Strep pyogenes Streptolysin O

Question 13

Lecithinase

Answer 13

C. perfringens Alpha toxin, degrades phospholipids leading to myonecrosis

Question 14

Superantigens

Answer 14

S. aureus TSST-1 and Strep pyogenes Exotoxin A

Question 15

Bring MHCII and TCR into proximity inducing overwhelming IFN-gamma and IL-2 release

Answer 15

S. aureus TSST-1 and Strep pyogenes Exotoxin A