W2/L6: Intro to the immune system Flashcards
1
Q
What do PAMPs bind to?
A
PRRs
2
Q
PAMP-PRR binding is a key part of which part of the immune system?
A
Innate
3
Q
Which are the cell-membrane PRRs? (7)
A
TLR-1 TLR-2 TLR-4 TLR-5 TLR-6 Dectin-1 Mannose R
4
Q
What are some endosomal PRRs? (3)
A
TLR-3
TLR-7
TLR-9
5
Q
What are the cytosolic PRRs?
A
RLH
NLR
6
Q
Which PRR binds to flagellin?
A
TLR-5
7
Q
Which PRR binds to LPS?
A
TLR-4
8
Q
Which PRRs bind extracellular peptidoglycan?
A
TLR-6-TLR-2
TLR-1-TLR-2
9
Q
Which PRRs bind nucleic acids, and which?
A
TLR-3: dsRNA
TLR-7: ssRNA
TLR-9: CpGDNA
RLH: viral RNA
10
Q
What 2 things can a pluripotent haemopoetic stem cell become?
A
Lymphoid progenitor
Myeloid progenitor
