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1. Foundation > Immunology Peer Tute 3 > Flashcards

Immunology Peer Tute 3 Flashcards

1
Q

What are the components of humoral immunity?

A

B cells

Abs

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2
Q

Humoral vs cellular immunity: which can undergo affinity maturation?

A

Humoral

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3
Q

Humoral vs cellular immunity: which can target intracellular antigens?

A

Cellular

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4
Q

Define epitope

A

The site on an antigen where the BCR/TCR binds

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5
Q

What are the two chains of an antibody?

A

Light chain

Heavy chain

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6
Q

What are the two domains of an antibody?

A

Fab (antigen-binding)

Fc (constant)

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7
Q

Which chains is the Fab region made of?

A

Heavy & light

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8
Q

Which chains is the Fc region made of?

A

Heavy only

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9
Q

Which domain determines isotype?

A

Fc

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10
Q

Which two isotypes are expressed on naive B cells?

A

IgM

IgG

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11
Q

Which isotype is the least common?

A

IgD

“IgDud”

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12
Q

Which isotype is the most abundant in plasma?

A

IgG

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13
Q

Which isotype provides transplacental immunity?

A

IgG

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14
Q

Which isotype structure maximises avidity?

A

IgM, as it has 5 binding sites

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15
Q

Which isotype is found mostly pre-bound to its cognate receptor?

A

IgE

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16
Q

Which isotype is important in type 1 hypersensitivities?

A

IgE

17
Q

Which isotype is important in parasite immunity?

A

IgE

18
Q

Which isotype provides mucosal immunity?

A

IgA

19
Q

Which Abs exist as a monomer?

A

IgG
IgE
IgA (sometimes)

20
Q

Which Abs exist as a dimer?

A

IgA

21
Q

Which Abs exist as a pentamer?

A

IgM

22
Q

What are some opsonins?

A

IgG
C3b
C5b

(‘b” for binding component)

23
Q

How does Ab-dependent cellular cytotoxicity work?

A

When the cell that an IgG has bound to is too large to be engulfed, the NK cells which have corresponding FcyR are recruited. They release perforin and granzymes to kill the cell.

24
Q

What’s the name of the receptor for IgG’s Fc region?

A

FcyR

Fc”gamma” receptor

25
Q

Which isotypes are best at triggering the complement cascade?

A

IgG

IgM

26
Q

What are the components of MAC?

A

C5bC6bC7BC8bC9b

27
Q

What 3 processes contribute to B cell diversity?

A

V region diversity
Junctional diversity
Combinatorial diversity

28
Q

What’s a 3rd form of B cell diversity and when does it happen?

A

Somatic hypermutation - only after B cell activation

1. Foundation (31 decks)

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