Immunology Peer Tute 4

Question 1

What’s the role of MHCs?

Answer 1

Antigen presentation

Question 2

What antigens can MHCs present?

Answer 2

Peptide only

Question 3

What’s the inheritance pattern of MHCs?

Answer 3

Co-dominance

Question 4

What’s another name for MHCs?

Answer 4

HLA

Question 5

How many HLAs do normal nucleated cells have? What are they?

Answer 5

6

1 x maternal and 1 x paternal HLA-A, -B, and -C

Question 6

How many HLAs do APCs have? What are they?

Answer 6

12

1 x maternal and 1x paternal HLA-A, -B, -C, -DP, -DQ, -DR

Question 7

Which cells don’t have MHCs?

Answer 7

RBCs

Question 8

Can a nucleated cell have only 5 types of HLA?

Answer 8

Yes!

If the maternal and paternal ones are the same

Question 9

What are the two pathways of antigen processing in a cell?

Answer 9

Cytosolic

Endosomal

Question 10

What type of HLA does cytosolic processing usually use?

Answer 10

MHC I

Cause it’s a normal cell showing that it’s infected

Question 11

What type of HLA does endosomal processing usually use?

Answer 11

MHC 2

Cause it’s only APCs that phagocytose antigens

Question 12

What does cross presentation refer to?

Answer 12

Endosomal antigens getting into the endoplasmic reticulum and being presented on MHC I’s