Atherosclerosis Flashcards
1
Q
Definition
A
Disease of elastic arteries and large and medium sized muscular arteries.
2
Q
Risk factors
A
Modifiable: smoking, HTN, hyperlipidemia, DM
Non modifiable: gender (men and post menopausal women), and positive fam Hx
3
Q
Progression
A
Inflammation important in pathogenesis:
1) endothelial cell dysfunction
2) MP and LDL accumulation
3) foam cell formation
4) fatty streaks
5) SMC migration via PDGF and FDF and proliferation, extracellular matrix deposition
6) fibrous plaque and complex atheromas
4
Q
Complications
A
Aneurysms, Ischemia, Infarcts, PVD, thromboemboli
5
Q
Location
A
Abdominal aorta > coronary artery > popliteal artery > carotid artery
6
Q
Symptoms
A
Angina, claudication, but can be asymptomatic
