Antianginal therapy Flashcards
1
Q
Goal
A
Reduction of myocardial O2 consumption
Decreases 1 or more of the determinants of MVO2:
EDV, BP, HR, contractility, ejection time
2
Q
Nitrate (affects preload)
A
EDV: low BP: low Contractility: high (reflex response) HR: high (reflex response) Ejection time: low MVO2: low
3
Q
Beta blockers (affects afterload)
A
EDV: high BP: low Contractility: low HR: low Ejection time: high MVO2: low
4
Q
Nitrates and beta blockers
A
EDV: no effect or decrease BP: low Contractility: little/no effect HR: low Ejection time: little/no effect MVO2: low
5
Q
Nifedipine similar to
A
Nitrate in effect
6
Q
Verapamil similar to
A
beta blockers in effect
7
Q
Contraindicated in angina
A
Pindolol and acebutolol;
partial beta agonists.
