Adrenergic Receptor Antagonist

Question 1

What are the alpha-1 anatogonist?

Answer 1

-zosin(somethings) treat hypertension and BPH

Prazosin and Terazosin

Question 2

Explain the receptor dopamine works on at different doses?

Answer 2

D1 = renal perfusion shock. Beta-1 = Increase HR. Alpha-1 = vasoconstriction

Question 3

What is more specific type of dopamine?

Answer 3

FenolDOPam acts on only D1

Question 4

What are the A-1 and A-2 antagonist(non-selective alpha)

Answer 4

Phening for alpha

Phentolamine and Phenoxybenzamine

Raynaud’s, frostbite, and pheochromocytoma

Question 5

What special about phenoxybenzamine?

Answer 5

Non-competitive blocker. So it is widespread and persistent

Question 6

What are the Beta-1 antagonist?

Answer 6

BAMB -olol

A-M are selective B1 antagonist

Betaxolol, Atenolol, Metoprolol, Bisoprolol

Question 7

What are the 3rd generation B1 and B2 antagonist? And why are they so useful

Answer 7

Notice they don’t end in -olol.
They are the Real MVP though, because they prolong life in CHF patients.

Carvedilol
Labet-alol

Question 8

How do you treat B1 overdose?

Answer 8

Glucagon: works by different receptor to reduce Adenylyl cyclase.

Question 9

Why are beta blockers used to treat HTN?

Answer 9

Because it is used to treat mild HTN in caucasian because they are renin problems

Question 10

Which non-selective beta antagonist is contract indicated in asthma patients?

Answer 10

Propanolol

Question 11

What are the beta blockers safe for asthma, diabetic, and peripheral vascular disease?

Answer 11

BAMB
Betaxolol
Atenolol
Metoprolol
Bisoprolol