Histamine and Serotonin Antagonist

Question 1

What are uses of H1 receptor antagonist?

Answer 1

Allergic reactions
Motion sickness
Nausea and vomiting in pregnancy
Sleep aids

Question 2

Difference between H1 receptor antagonist and 2nd generation H1 receptor antagonist?

Answer 2

2nd generation H1 receptor antagonist do not cross blood brain barrier.

Question 3

Which H1 receptor antagonist is used in antiemetic during pregnancy?

Answer 3

Promethazine

Question 4

What early H1 receptor antagonists?

Answer 4

Diphenhydramine
Tripelennamine
Cyclizine
Promethazine
Chlorpheniramine

Question 5

What are 2nd generation H1 receptor antagonist used for?

Answer 5

Allergic Rhinitis

Question 6

Example of 2nd generation H1 receptor antagonists are?

Answer 6

• Dine = Loratidine and Fexofenadine
• zine = Cetirizine
• Stine = Azelastine

Question 7

What are uses of H2 receptor antagonist?

Answer 7

Dyspepsia and duodenal ulcer

Question 8

How do H2 receptor antagonist work?

Answer 8

Blocks gastric acid

Question 9

Which H2 antagonist has antiandrogen effect(impotence & gynecomastia)?

Answer 9

Cimetidine.

It gives you C-cups

Question 10

What drug can you use instead of cimetidine?

Answer 10

Nizatidine

Damn a Nazi does a better job

Question 11

What are the H2 receptor antagonist?

Answer 11

The FAMily RAN into NAZI Company
Famotidine
Ranitidine
Nizatidine
Cimetidine

Question 12

Which drug is both antihistaminic and antiserotinergic?

Answer 12

Cyproheptadine

Question 13

What is Cyproheptadine used for?

Answer 13

Skin allergies(urticaria, anti-5HT1)
Diarrhea of carcinoid syndrome(anti-5HT2)

Question 14

Which 5HT3 receptor antagonist works as an antiemetic?

Answer 14

Odanestron

Question 15

Why is odanestron contraindicated in pregnancy?

Answer 15

Because of it’s chemotherapeutic effect

Question 16

What does Ketanserin do?

Answer 16

Selective 5HT2A, 2C receptor antagonist, as well as alpha1 and H1 receptor antagonist