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Pharmacology 2 > Dyshemoglobinemia > Flashcards

Dyshemoglobinemia Flashcards

1
Q

Why do we use hyperbaric oxygen?

A

Prevents lipid peroxidation and delayed neurologic sequelae in CO poisoning

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2
Q

Why are nitrite dangerous?

A

Turns RBC hemoglobin to methemoglobin

CN moves from Fe3+ on cytochromes to those in RBCs creating CYANOMETHEMOGLOBIN

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3
Q

Nitrite poisoning is particularly dangerous if there is a concurrent?

A

CO poisioning

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4
Q

How does sodium thiosulfate work?

A

Enhances normal metabolism of cyanide via rhodanase

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5
Q

What is hydroxycobalamin used to treat?

A

Binds with cyanide –> cyanocobalamin(B12)

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6
Q

When should hydroxycobalamin be used?

A

Smoke inhalation victims not improving with supportive care
Cyanide exposure
Nitroprusside at risk patients

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7
Q

What is the mechanism for methylene blue?

A

Cofactor of NADPH reductase

Gains electron, donates directly to reduce methemoglobin

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8
Q

When is methylene blue useful?

A

In methemoglobinemia >20-30% or with symptoms

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9
Q

What are side effects of methylene blue?

A

Hemolyctic anemia(weak oxidizing capability)

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Pharmacology 2 (15 decks)

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