3 - Heavy Metals Flashcards Preview

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Flashcards in 3 - Heavy Metals Deck (17):
1

What are the mechanisms of action of heavy metals?

  • Disrupt enzymatic and transport process
  • Loss of energy production
  • Loss of ion regulation
  • Potential carcinogenesis

2

What does arsenic (As) naturally occur as? 

arsenopyrite - most common arsenic containing mineral

3

What are the effects of arsenic?

  • Dermatological
  • Vasodilation
  • GI effects
  • CNS
  • Headache
  • Coma
  • "garlic breath"
  • Teratogenic
  • Carcinogenic

4

What is used to treat arsenic poisoning?

  • Dimercaprol (BAL - British Anti-Lewisite), dithioglycerol

5

What is the antidote for antimony?

dimercaprol

6

What is argyria and what causes it?

Bluish-grayish pigmentation of skin and mucous membranes, permanent - from silver and silver containing compounds

7

What are the signs of gold toxicity?

  • Dermatitis
  • Metallic taste in mouth
  • Proteinuria
  • GI symptoms
  • Aplastic anemia

8

What's the antidote for gold?

dimercaprol or penicillamine

9

What are the symptoms of people exposed to mercury?

  • Tremors
  • Impaired cognitive skills
  • Sleep disturbance

With acute exposure:

  • Chest pain
  • Dyspnea
  • Cough
  • Hemoptysis
  • Pulmonary function impairment
  • Interstitial pneumonia

10

What's the difference between elemental and inorganic mercury?

  • Elemental
    • Aquired in food (fish)
    • Neurotoxic 
    • Acute poisoning = pneumonitis
  • Inorganic 
    • Amalgam
    • Kidney damage, corrosive to oral cavity

11

What are the antidotes for mercury?

  • dimercaprol or penicillamine
  • N-acetyl-D
  • L penicillamine 

12

What is the enzyme inhibitor in the production of heme?

Lead (Pb)

13

What are the antidotes of lead?

Combination - calcium EDTA and dimercaprol

14

What's similar to lead poisoning, and inhibits the same processes as lead?

Cadmium

15

What is the antidote to Iron and Aluminum?

deferoxamine

16

What's the antidote to Nickel?

diethylthiocarbamate trihydrate

17