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mss > 3. Rheumatology and Immunology > Flashcards

3. Rheumatology and Immunology Flashcards

1
Q

Specificity is the likelihood that an individual with a disease will test […].

A

negative

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2
Q

Ferritin and fibrinogen are examples of […] acute phase reactants.

A

positive

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3
Q

[…] antigen positivity is a specific marker for mixed connective tissue disease.

A

RNP

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4
Q

RNP antigen positivity is a specific marker for […] disease.

A

mixed connective tissue

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5
Q

[…] antigen is associated with systemic sclerosis.

A

scl-70

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6
Q

scl-70 antigen is associated with […].

A

systemic sclerosis

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7
Q

[…] antibodies are useful in diagnosing limited scleroderma.

A

Anti-centromere

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8
Q

Anti-centromere antibodies are useful in diagnosing […].

A

limited scleroderma

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9
Q

[…] antibodies attack citrulline residues that form in the post-translational modification of arginine.

A

anti-cyclic citrullinated peptide

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10
Q

anti-cyclic citrullinated peptide antibodies attack citrulline residues that form in the post-translational modification of […].

A

arginine

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11
Q

[…] is a more sensitive marker for inflammation compared to ESR.

A

CRP

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12
Q

CRP is a more sensitive marker for inflammation compared to […].

A

ESR

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13
Q

[…] presents with CREST syndrome: calcinosis, raynauds, esophageal dysmotility, sclerodactyly, and telangiectasia.

A

Limited scleroderma

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14
Q

Limited scleroderma presents with […] syndrome: calcinosis, raynauds, esophageal dysmotility, sclerodactyly, and telangiectasia.

A

CREST

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15
Q

Limited scleroderma presents with CREST syndrome: […].

A

calcinosis, raynauds, esophageal dysmotility, sclerodactyly, and telangiectasia

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16
Q

Inherited deficiencies in the […],[…], and […] complement proteins can predispose a person to develop SLE.

A

C1,C2,C4

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17
Q

Inherited deficiencies in the C1,C2, and C4 complement proteins can predispose a person to develop […].

A

SLE

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18
Q

Inflammatory disorder of joints usually cause this type of anemia:

A

anemia of chronic disease (normochromic normocytic)

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19
Q

The […] and […] are the joint sites most commonly affected by rheumatoid arthritis.

A

MCP, PIP

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20
Q

The […] joint at the base of the thumb is a common site of osteoarthritis.

A

carpometacarpal

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21
Q

The carpometacarpal joint at the base of the thumb is a common site of […].

A

osteoarthritis

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22
Q

[…] is joint pain without any deformities seen on exam and this is seen in non-articular joint disorders.

A

Arthralgia

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23
Q

Arthralgia is joint pain without any deformities seen on exam and this is seen in […] joint disorders.

A

non-articular

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24
Q

Acute […] is suggestive of gout, trauma, or infection.

A

monoarthritis

25
Q

Acute monoarthritis is suggestive of gout, […], or infection.

A

trauma

26
Q

[…] and Procainamide are two medications known to cause lupus-like syndrome.

A

Hydralazine

27
Q

Hydralazine and […] are two medications known to cause lupus-like syndrome.

A

Procainamide

28
Q

Hydralazine and Procainamide are two medications known to cause […].

A

lupus-like syndrome

29
Q

The target structure in rheumatoid arthritis is the […].

A

synovium

30
Q

The […] MCP’s are the two more commonly involved MCP’s in rheumatoid arthritis.

A

2nd and 3rd

31
Q

The 2nd and 3rd MCP’s are the two more commonly involved MCP’s in […].

A

rheumatoid arthritis

32
Q

[…] is a common physical manifestation of rheumatoid arthritis.

A

Ulnar deviation

33
Q

Ulnar deviation is a common physical manifestation of […].

A

rheumatoid arthritis

34
Q

[…] is the presence of rheumatoid nodules in the lungs causing rheumatoid lung disease.

A

Caplan’s syndrome

35
Q

Caplan’s syndrome is the presence of rheumatoid nodules in the lungs causing […].

A

rheumatoid lung disease

36
Q

[…] occurs when patients with rheumatoid arthritis present with splenomegaly and a very low white blood cell count.

A

Felty syndrome

37
Q

Felty syndrome occurs when patients with rheumatoid arthritis present with […] and a very low white blood cell count.

A

splenomegaly

38
Q

The gold standard for the treatment of rheumatoid arthritis is […].

A

methotrexate

39
Q

Prior to using […] to treat rheumatoid arthritis, a PPD screening test must be done as there is a risk of disease reactivation.

A

TNF inhibitors

40
Q

Prior to using TNF inhibitors to treat rheumatoid arthritis, a […] test must be done as there is a risk of disease reactivation.

A

PPD screening

41
Q

The […] score is used to measure disease activity in rheumatoid arthritis.

A

das28

42
Q

A das28 score of <2.6 implies […] of rheumatoid arthritis.

A

remission

43
Q

One of the ways that […] affects the skin is by causing “weeping” of the tissues as well as the internal lining of organs and this is called serositis.

A

SLE

44
Q

One of the ways that SLE affects the skin is by causing “weeping” of the tissues as well as the internal lining of organs and this is called […].

A

serositis

45
Q

[…] is the only drug that has been approves for targeted therapy for SLE.

A

Belimumab

46
Q

Belimumab is the only drug that has been approves for targeted therapy for […].

A

SLE

47
Q

[…] works by blocking the BLyS protein thereby reducing B cell mediated immunity.

A

Belimumab

48
Q

Belimumab works by blocking the […] protein thereby reducing B cell mediated immunity.

A

BLyS

49
Q

[…] and […] antibodies are the two proteins to look for in association with SLE.

A

antidsDNA, anti-smith

50
Q

antidsDNA and anti-smith antibodies are the two proteins to look for in association with […].

A

SLE

51
Q

[…] is marked by significant hypergammaglobulinemia or abnormal blood proteins.

A

Sjogren’s syndrome

52
Q

Sjogren’s syndrome is marked by significant […] or abnormal blood proteins.

A

hypergammaglobulinemia

53
Q

A small subset of patients with […] can go on to develop MALT lymphoma.

A

Sjogrens syndrome

54
Q

A small subset of patients with Sjogrens syndrome can go on to develop […].

A

MALT lymphoma

55
Q

Class of drugs that should not be used in patients with sjogren’s syndrome?

A

TNF-alpha inhibitors

56
Q

[…] is the drug of choice for the sjogren patient with major organ involvement.

A

Azathioprine

57
Q

Azathioprine is the drug of choice for the sjogren patient with major […].

A

organ involvement

58
Q

[…] is a pain syndrome that involves abnormal pain processing by the CNS.

A

Fibromyalgia

mss (6 decks)

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