3.1 Autoimmunity and inflammation in MSK Flashcards Preview

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Flashcards in 3.1 Autoimmunity and inflammation in MSK Deck (12)
1

What joint is often used to tell RA from OA?

Distal IP joint - affected only in OA

2

What are the clinical manifestations of RA?

Morning stiffness for at least 1 hour and present for at least 6 weeks
Swelling of 3 or more joints for 6 weeks
Symmetrical joint swelling
Rheumatoid nodules
Erosions and bony declacification on x-ray

3

What will you see on testing for RA?

Rheumatoid factors or anti-citrullinated peptide/protein antibodies
Elevated acute phase reactants

4

What are the extra-articular manifestations of RA?

Rheumatoid nodules
Lung disease - pleural effusion, pneumonitis, interstitial lung disease, nodules
Pericarditis
Vasculitis
Neutropenia + splenomegaly
Scleritis and episcleritis

5

What is rheumatoid factor?

Antibody to Fc portion of IgG - present in 75% cases but not specific for RA (IgM correlates best with RA)

6

What is the gene locus thought to be associated with RA?

HLADRB1 (30%) - associated with more sever disease rather than risk of diseases

7

What joints are most commonly affected in seronegative arthritis?

Sacroiliac joint and axial skeleton (usually present with lower back pain more to one side)

8

What are the types of seronegative arthritis?

Ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel disease

9

What are the extra-articular features of seronegative arthritis?

Usually inflammation of tendon insertion (enthesitis)
Iritis
Urethritis
Skin disease
Keratoderma on feet

10

What is the gene thought to be associated with seronegative arthridities?

HLA-B27

11

What do you ALWAYS see in SLE?

Anti-nuclear antibodies

12

What are the key auto antigens in SLE?

usually chromatin, ribonucleases, phospholipids