3.1.2 Neisseria gonorrhoeae

Question 1

What are the virulence factor of N. gonorrhoeae?

Answer 1

Receptors to human transferrin

Outer membrane proteins
- Protein I (porB)
- Protein II (Opacity)
- Protein III (Reduction modified protein)

Pili

Capsule

Lipooligosaccharide (Endotoxins)

IgA protease

Question 2

This virulence factor binds to iron-carrying protein to steal the iron

Answer 2

Receptors for human transferrin

Question 3

What are the outer membrane protein for Neisseria gonorrhoeae?

Answer 3

Protein I (porB)
Protein II (Opacity)
Protein III (Reduction modified protein)

Question 4

What are the genes for protein I in outer membrane that is being secreted by Neisseria meningitidis?

Answer 4

porA and porB

Question 5

An outer membrane proteins that is a protective against inflammation and serum complement mediated killing

Answer 5

Protein I (porB)

Question 6

What is membrane attack complex? (MAC)

Answer 6

IT is where the complement attacks or kills the infected cells that has infected by bacteria

Question 7

An outer membrane protein that adheres to phagocytic and epithelial cells

Answer 7

Protein II (Opacity)

Question 8

An outer membrane that blocks host serum bactericidal IgG

(Block phagocytosis and response to lymphocytes which prevents in the production of antibodies)

Answer 8

Protein III (Reduction modified protein)

Question 9

How do you connect each outer membrane protein?

Answer 9

Protein II (Opacity) allows adherence of the bacteria to the phagocytes and the epithelial cell then the Protein I (porB) gene prevents MAC and inflammation which assist the Protein III (Reduced modified protein) to block phagocytosis and bactericidal and immune response leading to no production of antibodies

Question 10

What is the specific nutrient or growth requirement of N. gonorrhoeae?

Answer 10

Iron

Question 11

Pili has 5 distinct colony types?

Answer 11

T1 and T2 = Virulent
T3-T5 = no pili (Not virulent)

Question 12

What is the function of pili

Answer 12

attachment to host
Prevents phagocytosis
exchange genetic material

Question 13

Outer membrane proteins that create a channel for nutrients to pass into and waste products to exit cell

Answer 13

Protein I (porB)

Question 14

What is the function of capsule in N. gonorrhoeae

Answer 14

Prevents phagocytosis

Question 15

A virulence factor that mediates damage to body tissue and releases a outer membrane fragment (blebs)

Answer 15

Lipooligosaccharides or endotoxins

Question 16

What is the main vivo virulence factor of N. gonorrhoeae?

Answer 16

Lipooligosacchrides

Question 17

What is IgA protease?

Answer 17

Cleaves IgA mucosal surfaces

Question 18

What bacteria is the most sexually acquired from asymptomatic carriers

Answer 18

N. gonorrhoeae

Question 19

If female has N. gonorrhoeae?

Answer 19

Infection carrier

Question 20

If male has N. gonorrhoeae

Answer 20

Symptoms

Question 21

What are the clinical infections for N. gonorrhoeae?

Answer 21

Gonococcal urethritis and cervicitis

Conjunctivitis (Ophthalmia neonatorum)

Gonorrhea

Perihepatitis (Fitz-Hugh-Curtis syndrome)

Disseminated gonococcal disease

Extragenital infections
- pharyngitis
- Anorectal infections

Question 22

What is the meaning of Gonorrhea?

Answer 22

Flow of seed
Clap from french word

Question 23

Untreated Gonococcal urethritis and Cervicitis will lead to?

Answer 23

PID (Pelvic inflammatory disease

Sterility

Ectopic pregnancy

Fitz-Hugh-Curtis syndrome

Question 24

A vertically transmitted disease that can lead to blindness of a child or newborn

Answer 24

Conjunctivitis (Ophthalmia neonatorum)

Question 25

Gonorrhea is a acute pyogenic infection of the?

Answer 25

Pharynx Urogenital tract Conjunctiva of the eye (PUC)

Question 26

In male, what is the incubation period of gonorrhea?

Answer 26

2-7 days

Question 27

In male, what is the MOT of gonorrhea?

Answer 27

Sexual contact

Question 28

What is the meaning of Acute pyogenic infection?

Answer 28

Presence of pus formation

Question 29

What bacteria is One of the leading cause of STD?

Answer 29

Chlamydia trachomatis

Question 30

What are other bacteria/virus cause STD?

Answer 30

N. gonorrhoeae Chlamydia trachomatis human papilloma virus

Question 31

What are the symptoms of gonorrhea in males?

Answer 31

Dysuria

Question 32

A painful and difficult urination due to urinal discharge

Answer 32

Dysuria

Question 33

What are the complication of dysuria?

Answer 33

Epididymitis Urethral stricture Prostatitis infertility (EUPI)

Question 34

A complication of gonorrhea where an inflammation of small coiled tube of testicles

Answer 34

Epididymitis

Question 35

A complication of gonorrhea where a narrowing of urethra

Answer 35

Urethral stricture

Question 36

A complication of gonorrhea where inflammation of prostate

Answer 36

Prostatitis

Question 37

Females has many as 50% asymptomatic (carriers)

Answer 37

TRUE

Question 38

What are the symptoms of gonorrhea in females?

Answer 38

Dysuria Cervical discharge Lower abdominal pain

Question 39

What are the complication in females with gonorrhea?

Answer 39

PID which leads to - Sterility - Ectopic pregnancy - Fitz-Hugh-Curtis syndrome

Question 40

What is PID

Answer 40

an infection in 1 or more upper female reproductive organs

Question 41

What is the most common site of infection in gonorrhea in females?

Answer 41

Endocervix

Question 42

It is the inflammation of the Cervix

Answer 42

Cervicitis

Question 43

How to detect Cervicitis?

Answer 43

Papsmear

Question 44

A yellowish in color in Cervicitis

Answer 44

Vaginal discharge

Question 45

Why does PID lead to Ectopic Pregnancy?

Answer 45

Scarring of the fallopian tube

Question 46

A severe chronic inflammation of the liver capsule WITHOUT the involvement of liver parenchyma.

Answer 46

Fitz-Hugh-Curtis syndrome (Perihepatitis)

Question 47

In perihepatitis, where does the adhesion occur?

Answer 47

Inbetween Liver capsule and parietal peritoneum

Question 48

How does the infection occur in Perihepatitis

Answer 48

Due to scarring of the fallopian tube, bacteria passes through the liver capsule

Question 49

What do you call the adhesion in perihepatitis?

Answer 49

Violin String

Question 50

What happens if the fallopian tube is scar?

Answer 50

Infertile

Question 51

What is the first thing you do if you received a sample with this disease?

Answer 51

Gram Staining

Question 52

Example of Disseminated gonococcal disease

Answer 52

Blood-borne dissemination Gonococcal arthritis

Question 53

Majority of DGD/3-5% of men are asymptomatic due to what strains?

Answer 53

Arginine Hypoxanthine Uracil

Question 54

Blood borne dissemination is not recovered in Blood culture?

Answer 54

TRUE

Question 55

Blood borne dissemination, N. gonorrhoeae is inhibited by?

Answer 55

Sodium polyanethol sulfonate

Question 56

Gonococcal arthritis is also known as

Answer 56

Purulent arthritis

Question 57

Gonococcal arthritis is result from?

Answer 57

Disseminated gonococcal bacteremia

Question 58

What antimicrobial agent is useful in treating gonorrhea?

Answer 58

Penicillin

Question 59

It is an anti-coagulant to prevent the clotting of blood that is being put in the blood culture bottle.

Answer 59

Sodium polyanethol sulfonate

Question 60

What to add in Blood culture if you want to support the growth of N. gonorrhoeae?

Answer 60

Gelatin

Question 61

What is the most common extragenital infections in men having sex with men?

Answer 61

Anorectal infections

Question 62

What is the disease of the newborns in Extragenital infection?

Answer 62

Ophthalmia neonatorum

Question 63

Inflammation of tonsils?

Answer 63

Gonococcal pharyngitis

Question 64

What is use to treat Ophthalmia neonatorum?

Answer 64

Erythromycin

Question 65

If Ophthalmia neonatorum is left untreated, it will lead to?

Answer 65

Blindness

Question 66

What is the mode of transmission for Ophthalmia neonatorum?

Answer 66

Vertical transmission