3151 infection

Question 1

Nitrofurantoin (3)

Answer 1

Avoid in:
1. elderly
2. CrCl < 30
3. G6PD

Question 2

Co-trimoxazle (2)

Answer 2

avoid in
1. G6PD
2. Pregnancy: 1st & 3rd trimester

Question 3

Antibiotics safe (1) for pregnancy & avoid (6)

Answer 3

Beta lactams only
Avoid ciprofloxacin, co-trimoxazole, nitrofurantoin, Aminoglycosides, tetracyclines, triazoles

Question 4

Vancomycin ADR (4)

Answer 4

1. Red neck/man syndrome
2. Thrombophlebitis
3. Neurotoxicity
4. Ototoxicity

Question 5

Aminoglycoside ADRs (3)

Answer 5

1. Ototoxicity
2. Neurotoxicity
3. Myasthenia gravis (neuromuscular paralysis)

Question 6

Macrolides ADRs (3) + DDI (1)

Answer 6

1. Hepatotoxicity
2. Ototoxicity
3. QTc prolongation
   DDI: CYP3A4

Question 7

Linezolid ADR (3)

Answer 7

1. Bone marrow suppression
2. Serotonin syndrome
3. Peripheral neuropathies & optic neuritis (blindness)

Question 8

Fluoroquinolones ADRs

Answer 8

1. Aortic dissection
2. Phototoxicity
3. Peripheral neuropathy
4. Tendinitis / tendon rupture

Question 9

Fluoroquinolones CI (3)

Answer 9

1. breast feeding
2. myasthenia gravis
3. G6PD

Question 10

Co-trimoxazole ADRs (3)

Answer 10

1. Hyperkalaemia
2. Haemolytic anaemia
3. Folate deficiency

Question 11

Metronidazole ADRs (3)

Answer 11

1. Oral moniliasis (yeast infection)
2. seizure
3. optic & peripheral neuropathy

Question 12

Amphotericin B ADRs (4)

Answer 12

1. Bone marrow suppression
2. Thrombophlebitis
3. Nephrotoxicity
4. Electrolyte imbalance

Question 13

Triazoles ADRs (2) + DDI (1)

Answer 13

1. Hepatotoxicity
2. QTc prolongation
   DDI: CYP3A4

Question 14

Terbinafine CI (2)

Answer 14

1. Breast feeding
2. renal / hepatic impairment

Question 15

Rifampicin ADR (3) + DDI (1) + caution (1)

Answer 15

1. orange discolouration of body fluids
2. thrombocytopenia
3. Hepatitis
   DDI: CYP450
   Caution: give Vit K