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Semester Three > IIH L01-L04 Haematology block > Flashcards

IIH L01-L04 Haematology block Flashcards

1
Q

Which cell does IL-3 promote? L02

A

Stem cells and their early progenitors

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2
Q

Which cell does IL-5 promote? L02

A

Eosinophils

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3
Q

Which cell does IL-7 promote? L02

A

Lymphoid

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4
Q

Which cells degranulate in the acute inflammatory response? L01

A

Mast cells

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5
Q

What is opsonisation? L01

A

Process whereby a pathogen is marked for ingestion and destruction by a phagocyte

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6
Q

What are the three mechanisms for opsonisation? L01

A

Complement, immunoglobulins and CRP & other acute phase proteins

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7
Q

What cells are part of the innate immune system? L01

A

Neutrophils, monocytes, mast cells and dendritic cells

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8
Q

What cells are part of the adaptive immune system? L01

A

T and B cells

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9
Q

How does the innate immune system recognise pathogens? L01

A

Through Pattern Recognition Receptors which recognise the PAMP on the pathogen

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10
Q

What are the features of the adaptive immune system? L01

A

Highly specific, memory, takes 4-6 weeks

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11
Q

Where do T-cells develop? L01

A

Thymus

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12
Q

Where do B-cells develop? L01

A

Bone marrow

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13
Q

Where specifically do B cells mature in response to T cell antigen presentation? L01

A

Germinal centres and lymph nodes

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14
Q

What is the life span for granulocytes? L02

A

<48 hours

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15
Q

What is the life span for erythrocytes? L02

A

120 days

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16
Q

What is the life span for platelets? L02

A

10 days

17
Q

What cells are part of the myeloid lineage? L02

A

Granulocytes (neutrophils, eosinophils, basophils), erythrocytes, monocytes and macrophages

18
Q

What cells are part of the lymphoid lineage? L02

A

NK cells, T cells and B cells

19
Q

What do NK cells do? L02

A

Part of innate immune system, defend from tumours and virally infected cells

20
Q

What immunity do T cells cause? L02

A

Cell-mediated immunity

21
Q

What immunity do B cells cause? L02

A

Humoral

22
Q

What are the original pre-cursors to all blood cells called? L02

A

Haemopoeitic stem cells

23
Q

What type of ‘-potent’ are haemopoeitic stem cells? L02

A

Multipotent as they have the capacity to differentiate into cells of all blood lineages

24
Q

What is the name of the cell-surface glycoprotein that is an immunophenotypic marker of marrow cells? L02

A

CD34

25
Q

What does G-CSF do? L02

A

Stimulates bone marrow to produce granulocytes and stem cells and mobilise them into blood. Used for stem cell transplants and harvesting

26
Q

How many days after fertilisation does haemopoeisis occur? L02

A

17 days

27
Q

Where is red marrow found in an adult skeleton? L02

A

Axial skeleton

Semester Three (12 decks)

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