White Blood Cells

Question 1

Neutrophils

Answer 1

Short lived (7 hours)
Rapid movement
Maturation: 6-10 days
3-4 lobes

Question 2

Eosinophils
Location:
Defense again:
Mode of defense:
Nucleus:

Answer 2

Found in tissues
Defense against parasits, allergens, tumors
Can phagocytosis but usually release granule contents

Bilobes

Question 3

Basophil
Location:
Kind of reaction:
Mode of defense:
Nucleus:
Matures in:

Answer 3

Usually found in tissue
Immediate hypersensitivity reaction
Release granular contents (heparin, histamine)
Obscured nucleus
Fully mature in marrow

Question 4

Mast cells
Location:
Contains:
High affinity receptors for:
Nucleus:

Answer 4

In bone marrow, skin and mucosal epithelial cells
NOT in peripherial blood
Contain histamine
Uncommon
High affinity receptors for IgE
Round nucleus, blue granules

Question 5

IL3

Answer 5

Cytokine that promotes early differentiation of granulocyte and monocyte production

Question 6

Order of cell development

Answer 6

Myeloblast
promelocyte
myelocyte
metamyelocyte: can’t divide anymore
band
neutrophil

Question 7

DiGeorge Syndrome

Answer 7

Chromosome 22q11.2 deletion syndrome
Congenital absence of thymus
decreased T cells and immunodeficiency

Question 8

Lymphoblastic lymphoma

Answer 8

Malignancy of immature T cells, typically presenting with an anterior mediastinal mass