Overview of Immune System

Question 1

Primary lymphoid tissues

Answer 1

Bone marrow

Thymus

Question 2

Secondary lymphoid tissues

Answer 2

Lymph nodes
MALT/GALT
Spleen

Question 3

Reticulo-endothelial system (RES)

Answer 3

collection of macrophages that filters arterial (spleen), enteric (liver), and venous (lung) vascular systems

Question 4

Ab that fetus can make

Answer 4

IgM
Can’t cross placenta
Constant level throughout life

Question 5

Can cross placenta –> passive immunity

Answer 5

IgG
Maternal IgG decreases after birth
Individual IgG increases after birth. Max at 2 y/o

Question 6

Passed from mother to baby in breast milk

Answer 6

IgA

Question 7

Risk of infection =

Answer 7

(Dose x Virulence)/Resistance

Question 8

ID50 =

Answer 8

of administered organisms required to cause clinical disease in 50% of animals

Question 9

IS homeostasis set point shift

Horizontal shift to right

Answer 9

Greater risk of infection b/c less immune response = immunosuppression
Too little up-regulation

Question 10

IS homeostasis set point shift

Horizontal shift to left

Answer 10

Less tolerance –> greater immune response

Too much up-regulation –> damage to host

Question 11

IS homeostasis set point shift

Horizontal shift

Answer 11

Changes in immunosuppression/tolerance for same level of immune response

Question 12

IS homeostasis set point shift

Vertical shift

Answer 12

Changes in intensity of immune response for same degree of injury or number of organisms

Question 13

IS homeostasis set point shift

Vertical shift up

Answer 13

more inflammation and tissue damage

Question 14

IS homeostasis set point shift

Vertical shift down

Answer 14

less inflammation and tissue damage