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Undeleted > Skin > Flashcards

Skin Flashcards

1
Q

Layers of epidermis (deep to superficial)

A

Stratum Basale
Stratum Spinulosum
Stratum Granulosum
Stratum Corneum

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2
Q

Melanocytes and langerhans cells are found in ____

A

epidermis

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3
Q

____ make up of 90% of cells in epidermis.

A

Keratinocytes

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4
Q

Cells of the stratum basale are attached to the basement membrane by ____

A

hemidesmosomes

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5
Q

Keratinocytes of the stratum spinulosum and basale are attached to each other by ____

A

desmosomes

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6
Q

Cytoplasmic plaques of desmosomes composed of (2)

A

Plakoglobin

Desmoplakin

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7
Q

4 layers of basement membrane zone (superficial to deep)

A

Plasma membrane of basal keratinocytes
Lamina lucida
Lamina densa: type 4 collagen
Sub basal lamina

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8
Q

2 layers of dermis

A

Papillary dermis

Reticular dermis

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9
Q

Papillary dermis:
Made of ___
Contains (2)
Controlled by:

A

Loose connective tissue, mainly type 3 collagen
Meissner’s corpuscles, vascular networks
Sympathetic nervous system

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10
Q

Reticular dermis:
Made of ___
Function:
Contains:

A

Dense irregular connective tissue, mainly Type I collagen
Strength and elasticity
Glands and hair follicles

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11
Q

Vater-Pacini corpuscles

A

Mediate sense of pressure

Not affected by anesthesia

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12
Q

Tyrosinase

A

converts tyrosine to melanin within melanosomes in melanocytes

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13
Q

Found everywhere on skin except palms and soles

A

Sebaceous glands

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14
Q

Found mainly in axillae and genital regions

A

Apocrine glands

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15
Q

Sebaceous glands are under __ control

A

endocrine

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16
Q

Apocrine glands are under __ control

A

adrenergic sympathetic innervation

17
Q

Eccrine glands

A

sweat glands

18
Q

Pilosebaceous unit

A

Hair + sebaceous gland

19
Q

3 cycles of hair growth

A

Anagen: active growth phase
Catagen: growth arresting phase
Telogen: resting phase/shedding phase

20
Q

Hyponychium

A

skin underlying free end of nail

21
Q

3 major protein components of cornified envelope

Enzyme that catalyzes the crosslinks

A 
Loricrin
Involucrin
Keratolinin
"LIK the envelope"
Transglutaminase 1
22
Q

Major membraine lipids of stratum corneum

A

Ceramides

Tightly packed and highly impermeable to water

23
Q

Lamellar granule or keratohyalin granule?

Membrane bound

A

Lamellar granule

24
Q

Lamellar granule or keratohyalin granule?

Not membrane bound

A

Keratohyaline granule

25
Q

Lamellar granule or keratohyalin granule?

Location: upper spinous layers

A

Both

26
Q

Lamellar granule or keratohyalin granule?

Primary site of activity: Granular-cornified layer interface

A

Lamellar granule

27
Q

Metabolically inert, enucleated cells formed from keratinocytes in the viable lower layers of the epidermis

A

Corneocytes

28
Q

Lamellar granule or keratohyalin granule?

Primary site of activity: granular layer & cornified layer

A

Keratohyaline granule

29
Q

Lamellar granule or keratohyalin granule?

Deliver precursors of stratum corneum lipids into intercellular space

A

Lamellar granule

30
Q

Lamellar granule or keratohyalin granule?

Deliver free amino acids to outer layers of stratum corneum (filaggrin monomers)

A

Keratohyaline granule

31
Q

Lipid content of lamellar granule function:

A

Maintain vapor barrier and signaling cell turnover

32
Q

Filaggrin in cornified cells function:

A

Matrix protein that promotes aggregation of keratin filaments

33
Q

Sweat secretion controlled by ____

A

hypothalamus

34
Q

UVC =

A

200-290 ozone layer

35
Q

UVB =

A

290-320 Burning ray

36
Q

UVA =

A

320 - 400 Tanning ray

37
Q

Present in dermis and induce immediate hypersensitivity response

A

Mast cell

38
Q

Produce pro-inflammatory cytokines (IL-1) and express MHC class II antigens and intracellular adhesion molecules

A

Keratinocyte

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