Growth Control Mechs/Breast/Colon Cancer

Question 1

MLH1

Answer 1

Mismatch repair genes. Muts lead to microsatellite instability and is associated w/ knockout of TGF Beta tumor suppressor functions

Question 2

Probable Progression of Colon Cancer Muts

Answer 2

Loss of APC leads to chromsomal instability in metaphase, which can knock out p53

Question 3

2 Muts that can often occur w/ BRCA1 or 2 loss

Answer 3

Disabled PTEN or overactive PI3K

Question 4

HER2 Overexpression

Answer 4

Chronic activation of ras/MAPK pathway

Question 5

Gleevec Mech

Answer 5

Binds ATP-binding site of Abl kinase so it blocks it from phospho’ing target cell prots so can cure leukemia early. However, late stages relapse and possibly Abl muts can avoid

Question 6

Synthetic Lethality (what it is and example)

Answer 6

Cancer cells w/ specific deficit might be dependent on another pathway to survive, so knocking that out can kill the cell. Like myc-dependent tumors are destroyed by CDK1 inhibitors

Question 7

2-doxyglucose

Answer 7

Glycolysis inhibitor that can kill cells depending on anaerobic utilization of glucose