Targeted Therapy

Question 1

Bevacizumab

Answer 1

Binds VEGF

Question 2

Ibritumomab

Answer 2

Radiolabeled Ab against CD20, so gives very precise radiation

Question 3

Brentuximab

Answer 3

Conjugate Ab, so has toxin on it used for lymphomas, against CD30 for HL

Question 4

Rituximab Use and Risk

Answer 4

Good for lymphoid malignancies (Diffuse large B cell lymphoma, follicular lymphoma, CLL), but can result in HBV reactivation

Question 5

Cetuximab

Answer 5

EGFR1 target, works as long as don’t have downstream Ras mutation. Good for colorectal and H&N

Question 6

Trastuzumab

Answer 6

Herceptin

Question 7

Sunitinib

Answer 7

VEGFR intracellular blocker for RCC

Question 8

Imatinib

Answer 8

constitutively active c-KIT R (stem cell factor R) intracellular blocker in addition to Bcr-Abl blocker. Works in GIST. Must have kit mutation at exon 9 or 11. Cytosolic in CLL for Bcr-Abl

Question 9

Temsirolimus/Everolimus

Answer 9

mTOR inhibitors for transplants and some tumors. Increase opportunistic infection risk/pneumonia

Question 10

Vemurafenib/Dabrafenib

Answer 10

Good for melanoma mets with b-raf mutation V600E, but increase risk of squamos cell cancers

Question 11

Proteosome Inhibitors

Answer 11

Good for myeloma

Question 12

Sunitinib Notable SFX

Answer 12

Hand foot syndrome w/ calluses on weight bearing surfaces