GU Cancers

Question 1

Difference b/w Renal Papillary Adenoma and Carcinoma

Answer 1

Size, under or over 0.5cm

Question 2

Angiomyolipoma Association

Answer 2

Tuberosing Sclerosis

Question 3

Clear Cell Carcinoma Gross Appearance

Answer 3

Becomes yellow bc cells contain glycogen

Question 4

2 Carcinomas that use Veins for Mets

Answer 4

Renal and liver

Question 5

RCC Papillary Genetics

Answer 5

Trisomy 7 or c-met oncogene (on 7). Autosomal Dominant

Question 6

Urinary Bladder Squamos Cell Carcinoma 2 Associations

Answer 6

Chronic urinary cath

Chronic schistosomiasis

Question 7

Prostate Cancer Unique Bone Invasion

Answer 7

Osteoblastic. Can do PSA to test

Question 8

Prostate Cancer Hormonal Therapy Note

Answer 8

LHRH agonist good because neg feedback, but use antiandrogens with first so don’t get initial spike in T

Question 9

Degarelix

Answer 9

Prostate ca treatment that just lowers T, doesn’t need antiandrogen with it first

Question 10

Docetaxel

Answer 10

1st drug to increase survival and QoL with prostate ca

Question 11

Enzalutamide

Answer 11

Oral AR antagonist for advanced prostat ca: Blocks T binding to AR, blocks AR movement to nuc, inhibits DNA binding

Question 12

Radium 223

Answer 12

Targets bone mets

Question 13

Denosumab

Answer 13

RANKLi Treats fracture risk in prostate cancer and prostata ca treatments?